Clinical Observation on Modified Bushen Qiangdu Zhiwang Decoction in the Treatment of Patients with Ankylosing Spondylitis Complicated with Cardiovascular Involvement
OBJECTIVE:To probe into the clinical efficacy of modified Bushen Qiangdu Zhiwang decoction in the treatment of patients with ankylosing spondylitis complicated with cardiovascular involvement.METHODS:A total of 88 patients with ankylosing spondylitis complicated with cardiovascular involvement admitted into Shanghai Songjiang Fangta Hospital of Traditional Chinese Medicine,Shanghai Baoshan Hospital of Integrated Chinese and Western Medicine and the First Affiliated Hospital of Naval Medical University from Apr.2020 to Aug.2022 were selected to be divided into two groups via random number table method,with 44 cases in each group.The control group was given conventional Western medicine,while the observation group was given modified Bushen Qiangdu Zhiwang decoction based on the control group.The clinical efficacy,traditional Chinese medicine syndrome scores,scores of related scales(ankylosing spondylitis disease activity index,ankylosing spondylitis disease function index,Framingham risk score),serum inflammatory indicators(serum C-reactive protein,erythrocyte sedimentation rate and tumor necrosis factor α)and spinal mobility(finger-to-floor distance,pillow-to-wall distance and spinal mobility test)of both groups before and after treatment were observed,the incidences of major adverse cardiovascular events in 1-year follow-up were recorded.RESULTS:The total effective rate of observation group was 90.70%(39/43),significantly higher than 74.42%(32/43)of the control group,with statistically significant difference(P<0.05).After treatment,the traditional Chinese medicine syndrome scores,ankylosing spondylitis disease activity index scores,ankylosing spondylitis disease function index scores,Framingham risk scores and serum inflammatory indicators of both groups were lower than those before treatment,and the observation group were lower than the control group,with statistically significant differences(P<0.05).After treatment,the finger-to-floor distance and pillow-to-wall distances were lower and the spinal mobility tests were better in both groups than those before treatment,and the observation group was better than the control group,with statistically significant differences(P<0.05).During 1-year follow-up,the incidence of major adverse cardiovascular events in the observation group was lower than that in the control group,with statistically significant difference(P<0.05).CONCLUSIONS:The efficacy of modified Bushen Qiangdu Zhiwang decoction in treatment of patients with ankylosing spondylitis complicated with cardiovascular involvement is remarkable.
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