Efficacy of Modified Wendan Decoction in the Treatment of Acute Stage of Ischemic Stroke of Qi-Deficiency,Blood-Stasis and Phlegm-Obstruction and Its Effects on NT-proBNP,ICAM-1 and MCP-1
OBJECTIVE:To probe into the efficacy of modified Wendan decoction in the treatment of patients with acute stage of ischemic stroke of Qi-deficiency,blood-stasis and phlegm-obstruction and its effects on the levels of N-terminal pro-brain natriuretic peptide(NT-proBNP),intercellular adhesion molecule-1(ICAM-1)and monocyte chemoattractant protein-1(MCP-1).METHODS:A total of 100 patients with acute stage of ischemic stroke of Qi-deficiency,blood-stasis and phlegm-obstruction admitted into the hospital from May 2021 to May 2022 were selected as research objects,which were divided into control group and observation group using a random number table method,with 50 cases in each group.The control group was given conventional treatment,while the observation group received modified Wendan decoction based on the control group.The clinical efficacy,levels of NT-proBNP,NT-proBNP and MCP-1,the National Institutes of Health Stroke Scale(NIHSS)score,Modified Rankin Scale(mRS)score and traditional Chinese medicine(TCM)syndrome integral were compared between two groups.RESULTS:After 1 month of treatment,the total effective rate of the observation group was 94.00%(47/50),which was significantly higher than 80.00%(40/50)of the control group,with statistically significant difference(P<0.05).After 1 month of treatment,the NT-proBNP,NT-proBNP and MCP-1 levels of the observation group were significantly lower than those of the control group,the various hemorheological indicators(plasma viscosity,blood low-shear viscosity,blood high-shear viscosity,fibrinogen and hematokrit)of the observation group were significantly lower than those of the control group,with statistically significant differences(P<0.05).After 7 d and 1 month of treatment,the NIHSS scores of the observation group were lower than those of the control group;after 1 month of treatment,the mRS score and TCM integral of the observation group were lower than those of the control group,with statistically significant differences(P<0.05).CONCLUSIONS:The efficacy of modified Wendan decoction in the treatment of patients with acute stage of ischemic stroke of Qi-deficiency,blood-stasis and phlegm-obstruction is remarkable,which can significantly reduce the levels of NT-proBNP,NT-proBNP and MCP-1,improve blood circulation and disease recovery,promote patients'quality of life.
Ischemic strokeSyndrome of Qi-deficiency,blood-stasis and phlegm-obstructionWendan decoctionN-terminal brain natriuretic peptide precursorIntercellular adhesion molecule-1Monocyte chemoattractant protein-1
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