Clinical Efficacy of Ulinastatin Combined with Continuously Subcutaneous Administration of Insulin Pump in the Treatment of Diabetic Ketoacidosis Complicated with Septic Shock
OBJECTIVE:To probe into the clinical efficacy of ulinastatin combined with continuously subcutaneous administration of insulin pump in the treatment of diabetic ketoacidosis(DKA)complicated with septic shock.METHODS:A total of 80 patients with DKA complicated with septic shock admitted to Zhangjiakou First Hospital from Jun.2021 to Jul.2023 were selected to be divided into control group(40 cases)and research group(40 cases)via the random number table method.Both groups were given conventional treatment,the control group was given continuously subcutaneous insulin injection of insulin pump on the basis of conventional treatment,the research group was given ulinastatin for injection basis on the control group.The clinical indicators,acidosis and blood glucose indicators,T lymphocyte subsets,inflammation and oxidative stress indicators,adverse drug reactions and clinical efficacy were compared between two groups.RESULTS:The total effective rate of the research group was 90.00%(36/40),significantly higher than 72.50%(29/40)of control group,with statistically significant difference(P<0.05).The negative-conversion time of urine ketone body,recovery time of blood glucose and correction time of pH in the research group were shorter than those in the control group,with statistically significant differences(P<0.05).After treatment,the levels of blood lactic acid(Lac),blood ketone body(KET),fasting blood glucose(FBG),glycated hemoglobin(HbA1c),CD8+,tumor necrosis factor α(TNF-α),procalcitonin(PCT)and malondialdehyde(MDA)of both groups were decreased,the levels of Lac,KET,FBG,HbA1c,CD8+,TNF-α,PCT and MDA in the research group were lower than those in the control group,with statistically significant differences(P<0.05).After treatment,the levels of carbon dioxide binding power(CO2 CP),CD4+,CD3+,CD4+/CD8+and superoxide dismutase(SOD)of both groups increased,the levels of CO2 CP,CD4+,CD3+,CD4+/CD8+and SOD in the research group were higher than those in the control group,with statistically significant differences(P<0.05).The incidences of adverse drug reactions between the research group and control group[10.00%(4/40)vs.7.50%(3/40)]were not statistically significant(P>0.05).CONCLUSIONS:Ulinastatin combined with continuously subcutaneous administration of insulin pump in the treatment of DKA complicated with septic shock can improve clinical symptoms,acidosis,blood glucose indicators and immune function,regulate inflammation and oxidative stress,with significant therapeutic effect and safety.
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