360例住院患者氨基糖苷类抗感染药物使用情况分析
Application of Aminoglycoside Anti-Infective Drugs in 360 Inpatients
付观双 1周维英 2蔡芸 3梁蓓蓓 3沈正泽4
作者信息
- 1. 重庆医科大学药学院,重庆 400016;中国人民解放军总医院医疗保障中心药剂科药物临床研究室,北京 100853
- 2. 重庆医科大学药学院,重庆 400016;重庆市药物代谢研究重点实验室,重庆 400016
- 3. 中国人民解放军总医院医疗保障中心药剂科药物临床研究室,北京 100853
- 4. 重庆医科大学药学院,重庆 400016;重庆医科大学附属永川医院药学部,重庆 400016
- 折叠
摘要
目的:了解氨基糖苷类抗感染药物在住院患者中的使用情况,促进临床合理用药.方法:回顾性分析 2023 年 1 月 1 日至6 月 1 日某院全身性使用氨基糖苷类抗感染药物的住院患者的人口学资料、用药情况、病原学检查、联合用药情况、用药不良反应等,并进行统计分析.结果:共 360 例住院患者在此期间全身性使用氨基糖苷类抗感染药物,包括阿米卡星、依替米星和庆大霉素;其中男性患者 251 例,女性患者 109 例,平均年龄为(60.39±18.11)岁;患者使用氨基糖苷类抗感染药物主要用于治疗革兰阴性菌感染,且多与β-内酰胺类药物联合应用;202 例为治疗用药,治疗有效率为 91.09%(184/202);共有 25 例患者(占 6.94%)用药后血肌酐水平较前明显升高;133 例患者存在不合理用药,包括给药剂量不合理 24 例(占 18.05%)、联合用药不合理 39 例(占29.32%)、预防用药疗程不合理 52 例(占 39.10%)、围手术期给药时间不合理 25 例(占 18.80%)以及预防用药选择不合理 12 例(占 9.02%).结论:该院全身性使用氨基糖苷类抗感染药物的临床应用总体较为合理,但仍存在用药剂量不精确、联合用药不合理等问题,应在治疗药物监测的指导下合理用药,并在用药期间密切关注肾功能相关指标的变化.
Abstract
OBJECTIVE:To investigate the application of aminoglycoside anti-infective drugs in inpatients,so as to promote rational drug use in clinic.METHODS:Demographic data,drug administration,pathogen examination,drug combination,and adverse drug reactions of inpatients with systemic aminoglycosides anti-infective drugs in the hospital from Jan.1st to Jun.1st,2023 were retrospectively analyzed.RESULTS:A total of 360 inpatients were treated with amikacin,etimicin,and gentamicin during this period.There were 251 male patients and 109 female patients with an average age of(60.39±18.11)years.Aminoglycoside anti-infective drugs were mainly used in the treatment of Gram-negative bacterial infection,and were mostly combined with β-lactam drugs.Among 202 patients treated with medication,the effective rate was 91.09%(184/202).Serum creatinine of 25 patients increased significantly after treatment(6.94%).Totally 133 patients had irrational medication,including 24 cases of irrational dosage(18.05%),39 cases of improper drug combination(29.32%),52 cases of irrational prophylactic medication regimen(39.10%),25 cases of irrational timing of perioperative medication(18.80%),and 12 cases of irrational selection of prophylactic medication(9.02%).CONCLUSIONS:The clinical application of aminoglycoside anti-infective drugs in the hospital is generally rational,yet there are still some problems such as inaccurate dosage and irrational drug combination.Rational medication should be guided by therapeutic drug monitoring,and the changes of related indicators of renal function should be paid close attention during drug use.
关键词
氨基糖苷类药物/抗感染药物/合理用药/回顾性分析Key words
Aminoglycoside/Anti-infective drugs/Rational medication/Retrospective analysis引用本文复制引用
基金项目
重庆市临床药学重点专科建设项目(渝卫办[2023]69号)
重庆医科大学未来医学青年创新团队支持项目(W0067)
出版年
2024
国家科技期刊平台
NSTL
万方数据