摘要
目的:探讨替加环素对患者凝血功能及肝功能的影响.方法:收集 2019 年 1 月至 2022 年 6 月首都医科大学附属北京友谊医院 55 例使用替加环素抗感染治疗患者的临床资料,记录患者用药前(T0)、用药 7 d(T7)和用药结束时(Tf)的凝血功能指标水平,包括外周血纤维蛋白原(FIB)、活化部分凝血酶时间(APTT)、国际标准化比值(INR)、D-二聚体(D-Dimer)和血小板计数(PLT);记录患者T0、T7 和Tf 的肝功能指标水平,包括丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、总胆红素(TBIL)和白蛋白(ALB);对凝血功能和肝功能指标进行统计学分析.结果:使用替加环素治疗后,患者的FIB水平呈逐渐降低趋势,T7、Tf 的FIB水平低于T0,差异均有统计学意义(P<0.05);APTT延长,T7、Tf 的APTT长于T0,差异均有统计学意义(P<0.05);D-Dimer水平呈降低趋势,Tf 的D-Dimer水平低于T0,差异有统计学意义(P<0.05),提示替加环素对凝血功能有影响.使用替加环素治疗后,患者的T7、Tf 的ALT水平低于T0,差异有统计学意义(P<0.05),呈降低趋势;T7、Tf 的ALP、AST、TBIL和ALB水平与T0 比较,差异均无统计学意义(P>0.05),提示替加环素对肝功能无影响.结论:替加环素可引起FIB水平降低、APTT延长、D-Dimer水平降低,用药期间需严密监测患者的凝血功能,预防出血.
Abstract
OBJECTIVE:To explore the effects of tigecycline on coagulation function and liver function.METHODS:Clinical data of 55 patients receiving anti-infective treatment with tigacycline in Beijing Friendship Hospital,Capital Medical University from Jan.2019 to Jun.2022 were collected.Levels of coagulation function indicators including peripheral blood fibrinogen(FIB),activated partial thrombin time(APTT),international normalized ratio(INR),D-dimer and platelet count(PLT)were recordedbefore medication(T0),7 d after medication(T7)and at the end of medication(Tf).The levels of liver function indicators in T0,T7 and Tf were recorded,including alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL)and albumin(ALB).The coagulation function and liver function indicators were statistically analyzed.RESULTS:After treatment with tigecycline,the FIB level of patients showed a decreasing trend,and the FIB level of T7 and Tf was lower than that of T0,with statistically significant difference(P<0.05);the APTT of T7 and Tf was longer than that of T0,the difference was statistically significant(P<0.05);the D-dimer level showed a decreasing trend,and the D-dimer level of Tf was lower than that of T0,with statistically significant difference(P<0.05),suggesting that tigecycline had some effects on coagulation function.After treatment with tigecycline,ALT levels of T7 and Tf were lower than those of T0,the difference was statistically significant(P<0.05),showing a decreasing trend;the levels of ALP,AST,TBIL and ALB in T7 and Tf were not significantly different from those in T0,without statistically significant differences(P>0.05),suggesting that tigecycline had no effect on liver function.CONCLUSIONS:Tigecycline may cause a decrease in FIB levels,prolongation of APTT,and a decrease in D-dimer levels,and patients'coagulation needs to be closely monitored during administration to prevent bleeding.
基金项目
北京友谊医院科研启动基金项目(yygdktgl2021-3)
国家科技期刊平台
NSTL
万方数据