Medication Laws and Mechanism of Traditional Chinese Medicine in the Treatment of Chronic Atrophic Gastritis Complicated with Intestinal Metaplasia Based on Network Pharmacology and Data Mining
OBJECTIVE:To explore medication laws of traditional Chinese medicine in the treatment of chronic atrophic gastritis complicated with intestinal metaplasia,and to analyze the potential mechanism of common drug pairs.METHODS:CNKI,Wanfang and VIP databases were retrieved(from database establishment to Jun.30th,2022).Excel,SPSS Modeler 18.1 and SPSS Statistics 26 were used for frequency statistics,association rule analysis and cluster analysis of the included traditional Chinese medicine.Protein-protein interaction,Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were performed by using Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,GeneCards,STRING,Cytoscape and other tools to reveal the potential mechanisms.RESULTS:A total of 100 prescriptions were screened out,with 187 traditional Chinese medicines.The medicinal properties were mainly warm,calm and cold.The medicinal tastes were mainly bitter and sweet.The main meridians were spleen and stomach.There were 21 kinds of traditional Chinese medicine used more than 20 times.Atractylodes macrocephala koidz-Hedyotis diffusae herba was the most supported drug combination.The key components of Atractylodes macrocephala koidz-Hedyotis diffusae herba in the treatment of chronic atrophic gastritis complicated with intestinal metaplasia were quercetin,β-sitosterol and stigmasterol.The core targets were tumor protein p53,protein kinase B1 and transcription factor AP-1.The main pathways of action were tumor-associated pathways,hepatitis B virus and advanced glycosylation end(AGE)product-AGE receptor signaling pathways.Molecular docking results showed strong binding activity of 3 key components to 3 core targets.CONCLUSIONS:Traditional Chinese medicine in the treatment of chronic atrophic gastritis complicated with intestinal metaplasia mainly based on strengthening the spleen,regulating the Qi,clearing heat and promoting blood circulation.Atractylodes macrocephala koidz-Hedyotis diffusae herba exerts the therapeutic effects on chronic atrophic gastritis complicated with intestinal metaplasia from multiple components,multiple targets and multiple pathways,laying a theoretical foundation for further mechanism research.
Traditional Chinese medicineChronic atrophic gastritisIntestinal metaplasiaMedication lawsMechanism
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