Effects of Compound Kushen Injection Combined with DCF Chemotherapy Regimen on Postoperative Complications and Th17/Treg Balance in Patients with Gastric Cancer
OBJECTIVE:To probe into the effects of compound Kushen injection combined with DCF chemotherapy regimen on postoperative complications and Th17/Treg balance in patients with gastric cancer.METHODS:Totally 96 patients with gastric cancer who underwent surgical treatment in the hospital from Oct.2022 to Aug.2023 were extracted to be divided into the compound Kushen injection group and control group according to different treatment regimens,with 48 cases in each group.Both groups received radical surgery.The control group was treated with DCF chemotherapy regimen(docetaxel+cisplatin+5-fluorouracil),while the compound Kushen injection group received compound Kushen injection on the basis of the control group.The incidence of postoperative complications and changes in Th17,Treg,and Th17/Treg indicators were compared between two groups.RESULTS:After treatment,the incidence of complications in compound Kushen injection group was 10.42%(5/48),lower than 35.42%(17/48)in control group,the difference was statistically significant(P<0.05).After treatment,Th17 and Th17/Treg indicators in both groups were higher than those before treatment,and the compound Kushen injection group was significantly higher than the control group,the differences were statistically significant(P<0.05).After treatment,Treg indicators in both groups were lower than those before treatment,and the compound Kushen injection group was significantly lower than the control group,with statistically significant difference(P<0.05).CONCLUSIONS:Compound Kushen injection can regulate the imbalance of T cell subsets in patients with gastric cancer after surgery,improve immune function,reduce the incidence of postoperative complications,and is more conducive to the prognosis of patients.
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