Meta-Analysis on Correlation Between Statin Therapy and Prognosis of Esophageal Cancer
OBJECTIVE:To evaluate the correlation between statin therapy and prognosis of esophageal cancer based on Meta-analysis.METHODS:PubMed,Web of Science,the Cochrane Library and Embase databases were systematically retrieved to collect the relevant literature of correlation between statin exposure and prognosis of esophageal cancer from the establishment of the database to Sept.1st,2023.Stata 17.0 software was used to analyze prognosis indicators all-cause mortality and malignancy specific mortality.RESULTS:According to the inclusion and exclusion criteria,a total of 8 articles(26553 patients diagnosed with esophageal cancer)were included in the Meta-analysis.The combined results showed that statin therapy was significantly associated with all-cause mortality(HR=0.82,95%CI=0.77-0.87)and malignancy specific mortality(HR=0.78,95%CI=0.70～0.86)in patients with esophageal cancer.In the subgroup analysis,the above significant correlations existed.Sensitivity analysis and publication bias detection supported the stability of the results.CONCLUSIONS:Current study provides preliminary evidence that statins therapy is associated with a survival benefit in patients with esophageal cancer,yet more research is needed to validate the findings.
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