Effects of Simiao Yong'an Decoction Combined with Self-Adhesive Soft Silicone Rimmed Foam Dressing on Acrohemodynamics,EGF,Serum FGF21 and CTRP9 in Wagner Grade 1 to 2 Diabetic Feet
OBJECTIVE:To observe the effects of Simiao Yong'an Decoction combined with self-adhesive soft silicone edged-type foam dressing on the end-hemodynamics,epidermal growth factor(EGF),serum fibroblast growth factor-21(FGF21)and C1q tumor necrosis factor-associated protein 9(CTRP9)of Wagner Grade 1-2 diabetic feet.METHODS:A total of 102 patients with Wanger grade 1 to 2 diabetic feet admitted into the hospital from Feb.2020 to Jun.2023 were grouping via random number table method.Fifty-one cases in the control group was given self-adhesive soft silicone rimmed foam dressing,51 cases in the observation group received Simiao Yong'an decoction combined with self-adhesive soft silicone rimmed foam dressing.Clinical efficacy were compared between two groups,the patients'wound area and skin temperature at the lesion were measured,transcutaneous oxygen partial pressure at the dorsum of foot was detected,the visual analog scores(VAS)were recorded,the patients'arterial flow velocity and intravascular diameter at the dorsum of foot were detected,the microvascular basal perfusion volume at the dorsum of foot was measured,EGF,amyloid A(SAA),FGF-21,CTRP9 and lipoprotein-associated phospholipase A2(Lp-PLA2)levels were detected.RESULTS:The total effective rate of the observation group was 96.08％(49/51),higher than 80.39％(41/51)of the control group,with statistically significant difference(P＜0.05).After treatment,the VAS was lower,the wound area was smaller,the skin temperature and transcutaneous oxygen partial pressure were higher in the observation group than those in the control group,with statistically significant differences(P＜0.05).After treatment,the arterial flow velocity and intravascular diameter at the dorsum of foot was faster,the intravascular diameter and microvascular basal perfusion volume at the dorsum of foot were larger,the FGF21 level was lower,the CTRP9 level and EGF content were higher,the SAA and Lp-PLA2 contents were lower in the observation group than those in the control group,with statistically significant differences(P＜0.05).CONCLUSIONS:Simiayongan Decoction combined with self-adhesive soft silicone edging foam dressing in the treatment of Wagner Grade 1-2 diabetic foot patients can inhibit body inflammation,increase EGF level,regulate FGF-21 and CTRP9 levels,improve acroarterial blood flow dynamics and microvascular circulation,promote wound healing,relieve wound pain,increase skin temperature and transcutaneous oxygen partial pressure,and improve the treatment of patients with Wagner Grade 1-2 diabetic foot.Improve clinical efficacy.
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