Effects of Bifidobacterium Quadruple Viable Tablets on Intestinal Flora,Immune Function and Chemotherapeutic Neurotoxicity in Patients Undergoing Chemotherapy for Cervical Cancer
OBJECTIVE:To probe into the effects of Bifidobacterium quadruple viable tablets on intestinal flora,immune function and chemotherapeutic neurotoxicity in patients undergoing chemotherapy for cervical cancer.METHODS:A total of 92 patients with cervical cancer admitted into the hospital from May 2021 to May 2023 were selected for prospective study.All patients were divided into the control group and research group via random number table method,with 46 cases in each group.The control group was given TP regimen(paclitaxel+cisplatin)for chemotherapy,and the research group received Bifidobacterium quadruple viable tablets combined with TP regimen for chemotherapy,with 21 d as 1 cycle,both groups were treated for 4 cycles.The short-term efficacy of both groups,the intestinal flora,immune function indicators[T-lymphocyte subpopulations(CD3+,CD4+and CD4+/CD8+),immunoglobulin A(IgA)and immunoglobulin G(IgG)],serum efficacy-related markers[cytokeratin 19 fragment antigen 21-1(CYFRA21-1),fibroblast growth factor receptor 4(FGFR4)and Spondin-2]levels before and after treatment,quality of life and incidences of adverse drug reactions during chemotherapy were compared.RESULTS:The overall remission rate and total effective rate of the research group were respectively 69.57％(32/46)and 82.61％(38/46),the differences were not statistically significant(P＞0.05)when compared with 60.87％(28/46)and 71.74％(33/46)of the control group.The numbers of Bifidobacterium,Lactobacillus and Enterococcus colonies were higher,the number of Escherichia coli colonies was lower in the research group than those in the control group after 2 and 4 cycles of treatment;the CD3+,CD4+and CD4+/CD8+levels in peripheral blood,and the serum IgA and IgG levels in the research group were higher than those in the control group after 2 and 4 cycles of treatment;the serum CYFRA21-1,FGFR4 and Spondin-2 levels in the research group and the control group after 2 and 4 cycles of treatment were lower than those before treatment;the QOL and KPS scores of the research group were higher than those of the control group after 2 and 4 cycles of treatment,the differences were statistically significant(P＜0.05).The incidences of gastrointestinal reactions,renal function impairment,leukopenia and neurotoxicity during treatment in the research group were lower than those of the control group,with statistically significant differences(P＜0.05).CONCLUSIONS:Bifidobacterium quadruple viable tablets can relieve the effects of chemotherapy on intestinal flora and immune function of patients with cervical cancer,which helps to reduce the incidence of adverse drug reactions such as chemotherapy neurotoxicity and improve patients'quality of life.
万方数据
维普
