健脾通络方对糖尿病周围神经病变患者糖脂代谢、微循环的影响

Effects of Jianpi Tongluo Formula on Glucose and Lipid Metabolisms and Microcirculation in Patients with Diabetic Peripheral Neuropathy

祖立斌 ¹张颖 ²王东军 ³张英来 ⁴贾洪伟⁴

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作者信息

1. 唐山市中医医院老年病科,河北唐山 063000
2. 唐山市丰南区中医医院内二科,河北唐山 063300
3. 华北理工大学中医学院中医系,河北唐山 063210
4. 唐山市中医医院内分泌二科,河北唐山 063000
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摘要

目的:探讨健脾通络方对糖尿病周围神经病变(DPN)患者糖脂代谢及微循环的影响.方法:选择2021年9月至2022年5月唐山市丰南区中医医院收治的DPN患者80例,通过随机数字表法分为对照组、观察组,各40例.对照组患者使用甲钴胺治疗,观察组患者在对照组的基础上加用健脾通络方治疗.比较两组患者的血糖指标、血脂指标、微循环指标、神经传导速度和临床疗效.结果:治疗后,两组患者糖化血红蛋白、空腹血糖和餐后2 h血糖水平降低,且观察组患者降低幅度更为显著,差异均有统计学意义(P＜0.05);治疗后,两组患者低密度脂蛋白胆固醇、总胆固醇和三酰甘油水平降低,高密度脂蛋白胆固醇水平升高,且观察组患者改善幅度更显著,差异均有统计学意义(P＜0.05);治疗后,两组患者内皮素-1水平降低,一氧化氮水平升高,且观察组患者内皮素-1降低幅度和一氧化氮升高幅度明显优于对照组,差异均有统计学意义(P＜0.05);治疗后,两组患者正中神经和腓总神经的感觉传导速度、运动传导速度升高,且观察组患者各项传导速度较对照组明显更高,差异均有统计学意义(P＜0.05).观察组、对照组患者的临床总有效率分别为95.00％(38/40)、75.00％(30/40),观察组患者显著高于对照组,差异有统计学意义(P＜0.05).结论:健脾通络方能够有效改善DPN患者的糖脂代谢水平和微循环指标.

Abstract

OBJECTIVE:To probe into the effects of Jianpi Tongluo formula on glucose and lipid metabolisms and microcirculation in patients with diabetic peripheral neuropathy(DPN).METHODS:Eighty patients with DPN admitted into Tangshan Fengnan District Traditional Chinese Medicine Hospital from Sept.2021 to May 2022 were extracted to be divided into the control group and observation group via the random number table method,with 40 patients in each group.The control group was treated with methylcobalamin,while the observation group received Jianpi Tongluo formula on the basis of control group.The blood glucose,lipid,microcirculation,nerve conduction velocity,and clinical efficacy of two groups were compared.RESULTS:After treatment,the levels of glycated hemoglobin,fasting blood glucose,and 2 hours postprandial blood glucose in both groups decreased,and the observed group showed a more obvious decrease,with statistically significant differences(P＜0.05).After treatment,the levels of low-density lipoprotein cholesterol,total cholesterol,and triglycerides in both groups decreased,while high-density lipoprotein cholesterol increased,the decrease and increase of the observation group were more significant,with statistically significant differences(P＜0.05).After treatment,both groups had a decrease in endothelin-1(ET-1)and an increase in nitric oxide(NO),and the observed group had a greater decrease in ET-1 and an increase in NO than the control group,with statistically significant differences(P＜0.05).The sensory conduction velocity and motor conduction velocity of the median nerve and common peroneal nerve were improved after treatment in both groups,and the observation group had higher conduction velocities,with statistically significant differences(P＜0.05).The total clinical effective rate was 95.00％(38/40)in the observation group and 75.00％(30/40)in the control group,the clinical efficacy of the observation group was obviously higher than that of the control group,with statistically significant differences(P＜0.05).CONCLUSIONS:Jianpi Tongluo formula can effectively improve the glucose and lipid metabolisms and microcirculation indicators in patients with DPN.

关键词

健脾通络方/糖尿病周围神经病变/糖脂代谢/微循环

Key words

Jianpi Tongluo formula/Diabetic peripheral neuropathy/Glucose and lipid metabolisms/Microcirculation

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基金项目

河北省自然科学基金资助项目(H2023209049)

河北省中医药管理局2022年度中医药类科研计划项目(2022554)

出版年

2024

中国医院用药评价与分析

中国医药生物技术协会，中国药房杂志社

中国医院用药评价与分析

CSTPCD

影响因子：1.142

ISSN：1672-2124

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