Clinical Efficacy of Wenyang Huoxue Tongluo Decoction Combined with Transcutaneous Electrical Acupoint Stimulation in the Treatment of Discogenic Low Back Pain and Its Effects on Serum PGE2 and 6-keto-PGF1α
OBJECTIVE:To probe into the clinical efficacy of Wenyang Huoxue Tongluo decoction combined with transcutaneous electrical acupoint stimulation in the treatment of discogenic low back pain and its effects on serum prostaglandin E2(PGE2)and 6-keto-prostaglandin F1α(6-keto-PGF1 α).METHODS:A total of 112 patients with discogenic low back pain admitted into the hospital from Jun.2021 to Jun.2022 were extracted to be divided into the control group and study group via the random number method,with 56 cases in each group.The control group was treated with transcutaneous electrical acupoint stimulation,while the research group received Wenyang Huoxue Tongluo decoction combined with transcutaneous electrical acupoint stimulation.The course of treatment in both groups was 2 weeks.The curative effect was statistical at the end of the course of treatment.The traditional Chinese medicine syndrome scores,efficacy index and brain low-frequency fluctuations(ALFF),neuromuscular function,serum sclerostatin(SOST),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),PGE2 and 6-keto-PGF1αbefore and after treatment were compared between two groups.RESULTS:The total effective rate of the research group was 96.43％(54/56),significantly higher than 83.93％(47/56)of the control group,the difference was statistically significant(P＜0.05).After treatment,the scores of cold limbs,numb limbs,local fixation tingling and purple dark limbs in research group were significantly lower than those in control group,with statistically significant differences(P＜0.05).After treatment,JOA score and leg lift in research group were significantly higher than those in control group,sitting time was significantly longer than that in control group,and VAS score was significantly lower than that in control group;the mean iEMG and mean RMS of muscle dorsal group were significantly higher than those of control group,serum levels of SOST,TNF-α and IL-6 were significantly lower than those of control group,serum levels of PGE2,6-keto-PGF1α were significantly lower than those of control group,the ALEF of left and right middle occipital gyrus was higher than that of control group,with statistically significant differences(P＜0.05).CONCLUSIONS:The efficacy of Wenyang Huoxue Tongluo decoction combined with transcutaneous electrical acupoint stimulation in the treatment of patients with discogenic low back pain is significant,which can reduce the levels of serum PGE2 and 6-keto-PGF1α,and relieve pain.The mechanism may be by changing the ALEF of the resting state of the brain,while enhancing neuromuscular function and decreasing SOST expression levels.
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