Clinical Comprehensive Evaluation of Magnesium Valproate Sustained-Release Tablets in the Treatment of Manic Episodes
OBJECTIVE:To evaluate the comprehensive clinical value of Magnesium valproate sustained-release tablets in the treatment of manic episodes,so as provide evidence support for clinical rational medicationand relevant medication decisions.METHODS:PubMed,the Cochrane Library,CNKI,Wanfang Data,and other Chinese and English databases were systematically retrieved(the retrieval time was from database establishment to Jul.1ist,2023)to collect the randomized controlled trial of Magnesium valproate sustained-release tablets in the treatment of manic episodes(the study group was treated with Magnesium valproate sustained-release tablets or combined with conventional antimanic drugs,while the control group received conventional antimanic drugs).The method of literature research was adopted,based on the current available evidence,a clinical comprehensive Evaluation of Magnesium valproate sustained-release tablets in the treatment of manic episodes was carried out around six dimensions of effectiveness,safety,economy,innovation,suitability,and accessibility.RESULTS:A total of 20 randomized controlled trials were included in the Meta-analysis.In terms of effectiveness,the total effective rate of Magnesium valproate sustained-release tablets in improving manic symptoms was similar to quetiapine and lithium carbonate(OR=1.19,95％CI=0.94-1.49,P=0.14).In terms of safety,the incidence(OR=0.57,95％CI=0.37-0.89,P=0.01)and severity(MD=-1.23,95％CI=-1.70--0.75,P＜0.000 01)of adverse drug reactions such as dizziness,headache and fatigue in patients using Magnesium valproate sustained-release tablets were lower than those of control drugs.In terms of economy,the minimum-cost analysis showed that Magnesium valproate sustained-release tablets were more economical than quetiapine.In terms of innovation,Magnesium valproate sustained-release tablets,produced by Hunan Xiangzhong Pharmaceutical Co.,LTD.,could increase the content of inhibitory transmitter in the brain through multiple ways.As the only magnesium valproate preparation in the world at present,the preparation process and appearance of Magnesium valproate sustained-release tablets are protected by patents.In terms of suitability,Magnesium valproate sustained-release tablets had good technical characteristics and suitability,easy to use and store.In terms of accessibility,Magnesium valproate sustained-release tablets was also included in the National Reimbursement Drug List with wide hospital coverage and high affordability.CONCLUSIONS:As the drug independently produced and developed in China,Magnesium valproate sustained-release tablets has good advantages in safety,effectiveness and economy,with innovative mechanism of action,good suitability,availability and affordability.
Magnesium valproate sustained-release tabletsManic episodesClinical comprehensive evaluation of drugs
万方数据
维普
