OBJECTIVE:To quantitatively and objectively evaluate the five original dipeptidyl peptidase-4(DPP-4)inhibitors,so as to provide quantitative reference for medical institutions to select drugs and provide basis for clinical drug selection.METHODS:Following the Rapid Guide for Drug Evaluation and Selection in Medical Institutions in China(Second Edition)(hereinafter referred to as"the guideline"),quantitative scores of five DPP-4 inhibitors were performed on five dimensions:pharmaceutical characteristics,effectiveness,safety,economy,and others attributes.RESULTS:All DPP-4 inhibitors included in the evaluation had scores＞70 points,in the order of sitagliptin 79.0 points,vigagliptin 72.8 points,saxagliptin 76.1 points,ligagliptin 78.7 points and alogliptin 76.9 points.CONCLUSIONS:Based on the guideline criteria,the five original DPP-4 inhibitors included in this evaluation are all"retained"and strongly recommended.However,this drug evaluation has more dimensions and the drugs involved have different advantages in each dimension.Each medical institution can adopt the evaluation results according to the evaluation rules and weights,and in accordance with the characteristics and actual needs of the medical institution.
维普
万方数据