OBJECTIVE:To probe into the clinical application rationality of paclitaxel injection(albumin-bound)in the treatment of malignant tumors in Suzhou Hospital of Traditional Chinese Medicine,so as to provide reference for clinical rational medication.METHODS:Retrospective investigation and analysis were adopted to evaluate the rationality of medication by summarizing information on the medication characteristics of patients receiving paclitaxel injection(albumin-bound)in Suzhou Hospital of Traditional Chinese Medicine from Jan.1st 2022 to Jan.1st 2024 through the hospital information system.RESULTS:A total of 106 patients received paclitaxel injection(albumin-bound)in 840 cases,and there were 396 cases of irrationality,with an irrationality rate of 47.14％,which mainly manifested in off-label indication of medication without evidence of evidence-based medicine(98 cases,11.67％),improper usage and dosage(207 cases,24.64％),unreasonable drug combination(2 cases,0.24％)and improper antiemetic pretreatment(346 cases,41.19％).Common adverse drug reactions were fatigue and weakness,hematotoxicity and peripheral neurotoxicity,with incidences of 66.67％(560 cases),45.60％(383 cases)and 12.14％(102 cases),respectively.CONCLUSIONS:Paclitaxel injection(albumin-bound)is widely used in the treatment of various malignant tumours,and the phenomenon of irrational clinical application is common,which needs to attract clinical attention,and pharmacists need to do a good job of pharmacological supervision to ensure medication safety.
关键词
注射用紫杉醇(白蛋白结合型)/用药分析/药品不良反应/药学监护
Key words
Paclitaxel injection(albumin-bound)/Drug analysis/Adverse drug reactions/Pharmaceutical care
维普
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