OBJECTIVE:To probe into the effects of national centralized drug volume-based procurement policy,drug negotiation and key monitoring on application of proton pump inhibitors(PPI)in hospitals,so as to provide data support for the rational application of PPI and evaluation of implementation effect on related policies.METHODS:Application data of PPI from 2018 to 2022 were extracted from the drug use database of sample hospitals of the National Pharmaceutical Information Network(including 892 hospitals,with 645 tertiary hospitals and 247 secondary hospitals).Consumption amount and proportion,consumption sum and proportion,daily defined dose system(DDDs)and daily defined dose(DDC)and other indicators were analyzed and compared.RESULTS:From 2018 to 2022,due to the influence of relevant policies,the consumption sum and DDC of PPI in sample hospitals decreased year by year.The reduction of PPI injection was greater than that of PPI oral preparation.The consumption amount structure and consumption sum structure of PPI changed significantly.The consumption amount of PPI injection and DDDs of most injection varieties decreased significantly.CONCLUSIONS:From 2018 to 2022,Consumption sum and consumption amount of PPI injection in sample hospitals decrease significantly,yet the alternative application among different clinical varieties still deserves further evaluation.
关键词
国家药品集中带量采购政策/质子泵抑制剂/用药频度/限定日费用/合理用药
Key words
National centralized drug volume-based procurement policy/Proton pump inhibitor/Defined daily dose system/Defined daily cost/Rational drug application
万方数据