Efficacy of Taoren Honghua Decoction Combined with Rehabilitation Training in the Treatment of Patients with Ischemic Stroke and Its Effects on GDF-15,SIRT1 and MMP-9 Levels
OBJECTIVE:To probe into the efficacy of Taoren Honghua decoction combined with rehabilitation training in the treatment of patients with ischemic stroke and its effects on growth differentiation factor-15(GDF-15),silent information regulatory factor 1(SIRT1)and matrix metalloproteinase-9(MMP-9)levels.METHODS:A total of 84 patients with ischemic stroke admitted into Dingzhou People's Hospital from Feb.2022 to Jul.2023 were extracted to be divided into the combined group and training group through the random number table method,with 42 cases in each group.The training group was given rehabilitation training on the basis of routine treatment,while the combined group was treated with Taoren Honghua decoction on the basis of the training group.The clinical efficacy,National Institutes of Health stroke scale(NIHSS)score,Modified Barthel Index(MBI),serum inflammatory factors[interleukin(IL)1β,IL-6 and tumor necrosis factor α(TNF-α)],oxidative stress related indicators[superoxide dismutase(SOD),malondialdehyde(MDA)],and serum levels of GDF-15,MMP-9 and SIRT1 of two groups were observed.RESULTS:The total clinical effective rate of the combined group was 95.24%(40/42),significantly higher than 78.57%(33/42)of the training group,with statistically significant differences(P<0.05).Compared with before treatment,the NIHSS score,IL-1β,IL-6,TNF-α,MDA,GDF-15 and MMP-9 levels in both groups decreased significantly after treatment,the MBI score,SOD and SIRT1 levels increased significantly,with statistically significant differences(P<0.05).Compared with the training group,the NIHSS score,IL-1β,IL-6,TNF-α,MDA,GDF-15 and MMP-9 levels in the combined group decreased significantly after treatment,the MBI score,SOD and SIRT1 levels increased significantly,with statistically significant differences(P<0.05).CONCLUSIONS:The clinical efficacy of Taoren Honghua decoction combined with rehabilitation training in the treatment of patients with ischemic stroke is significant,which can effectively improve the neurological function and cerebral hypoxia ischemia-reperfusion injury,reduce inflammation and stress response,and significantly increase the SIRT1 levels and reduce the GDF-15 and MMP-9 levels.
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