Systematic Review on Efficacy and Safety of Hydroxyethyl Starch Combined with Atorvastatin in the Treatment of Elderly Patients with Cerebral Watershed Infarction
OBJCETIVE:To systematically review the efficacy and safety of hydroxyethyl starch combined with atorvastatin in the treatment of elderly patients with cerebral watershed infarction.METHODS:Randomized controlled trials on the clinical efficacy and safety of hydroxyethyl starch combined with atorvastatin(observation group)versus atorvastatin alone(control group)in the treatment of elderly patients with cerebral watershed infarction based on basic treatment were retrieved from PubMed,CBM,CNKI,Wanfang Data and VIP databases(the retrieval time was from database establishment to Jan.2024),RevMan 5.3 statistical software was adopted to conduct Meta-analysis after data extraction and quality evaluation on the clinical researches that matched the inclusion criteria.RESULTS:A total of 18 RCT including 1 632 patients were enrolled.Meta-analysis indicated that the total effective rate(RR=1.25,95%CI=1.20-1.31,P<0.000 01),Barthel index(MD=10.42,95%CI=8.93-11.90,P<0.000 01)and ADL score(MD=12.25,95%CI=11.02-13.48,P<0.000 01)of the observation group were significantly higher than those of the control group,the NIHSS score(MD=-3.11,95%CI=-3.52--2.70,P<0.000 01)and incidence of three major adverse drug reactions(upper gastrointestinal hemorrhage,pulmonary infection and depression after cerebrovascular disease)were significantly lower than those of the control group(P<0.000 01),the differences were statistically significant.CONCLUSIONS:The clinical efficacy and safety of hydroxyethyl starch combined with atorvastatin in the treatment of elderly patients with cerebral watershed infarction are better than atorvastatin alone.
国家科技期刊平台
NSTL
万方数据
