Literature Case Analysis of Immune-Related Myocarditis Induced by Camrelizumab for Injection
OBJECTIVE:To investigate the clinical characteristics,treatment and outcome of immune-related myocarditis induced by carrilizumab for injection,so as to promote the safe application in clinic.METHODS:Wiley Online Library,Embase,PubMed,CBM,Wanfang Data,CNKI,VIP databases were retrieved to collect case report literature of immune-related myocarditis induced by carrilizumab for injection.The retrieval time was from the establishment of the database to Jul.2024.Statistical analysis was performed on basic information,medication regimen and drug combination,complication,onset time of myocarditis,outcome and intervention in the included literature.RESULTS:A total of 25 articles were enrolled,including 26 patients,with 14 males and 12 females.The age distribution was from 45 to 79 years,with a mean age of 64.7 years.The clinical diagnosis was mainly lung cancer in 9 cases;9 patients had previous medical history,3 of which had a history of diabetes.There were 21 cases with drug combination.The onset of myocarditis in 11 patients was after the first administration cycle of carrilizumab for injection,and the earliest was 2 d after the first administration.The most common clinical manifestations included chest tightness,fatigue,dyspnea,muscle weakness or soreness,and 15 patients were combined with other immune-related adverse drug reactions.19 patients were improved,3 patients did not improve,and 4 patients died.When myocarditis developed,all patients were promptly given glucocorticoids,and two had a permanent pacemaker implanted.CONCLUSIONS:It is suggested that baseline examination and routine monitoring of cardiac function should be done well when patients are treated with camrelizumab for injection.Close observation should be made during treatment,once the patient is suspected to have immune-related myocarditis,early intervention should be taken to ensure the medication safety.
Camrelizumab for injectionAdverse drug reactionImmune-related myocarditis
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