由Fonsecaea monophora所致以假水疱为主要表现的着色芽生菌病1例
A case of chromoblastomycosis with pseudoblister as the main manifestation caused by Fonsecaea monophora
郭艳阳 1张喆 1海璐明 1廖文俊 1闫东 1朱冠男 1王刚 1付萌1
作者信息
- 1. 空军军医大学西京皮肤医院检验科,西安 710032
- 折叠
摘要
报告以假水疤为主要表现的着色芽生菌病1例.患者女性,77岁,左前臂红色斑块、结痂4年,其上见细小假水疱样皮损.组织病理见混合性炎细胞浸润及硬壳细胞.组织沙堡弱培养基28 ℃培养见棕黑色菌落,中央呈灰黑色,菌落生长慢.小培养见枝孢和喙枝孢型混合产孢.分子测序比对为F.monophora.给予口服伊曲康唑200 mg,1次/日,盐酸特比萘芬片250 mg,1次/日,4个月后改为口服伊曲康唑200 mg,1次/日,3个月,配合温热疗法,皮损基本痊愈,随访无复发.
Abstract
A case of chromoblastomycosis with pseudoblister as the main manifestation is reported.The patient was a 77 year old female with red plaque and scab on her left forearm for 4 years.Histopathology showed mixed inflammatory cell in-filtration and muriform cells.Brown black colonies could be seen in the tissue Sabaouraud's medium at 28 ℃,the center was gray black,and the growth of colonies was slow.Cladospora and Rhinocladiella were mixed in small culture.The molecu-lar sequencing alignment was F.monophora.Oral itraconazole 200 mg/d and terbinafine hydrochloride tablets 250 mg/d was given for 4 months,then changed to oral itraconazole 200 mg/d for 3 months.Combined with hyperthermia therapy,the skin lesions were basically cured,and there was no recurrence during follow-up.
关键词
Fonsecaea/monophora/着色芽生菌病/硬壳细胞Key words
Fonsecaea monophora/chromoblastomycosis/muriform cells引用本文复制引用
基金项目
国家自然科学基金(82173409)
陕西省自然科学基金面上项目(2020JM-323)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据