Analysis to drug resistance characteristics and risk factors of Candida infection in elderly patients of a terti-ary traditional Chinese medicine hospital in Guangzhou
Objective To explore the drug resistance characteristics and risk factors of Candida infection among elderly pa-tients in the tertiary TMC Hospital in Guangzhou.Methods 44 elderly patients(aged≥60 years)with Candida nosocomi-al infection from January 2020 to December 2022 were selected as the infection group.According to the 1:1 ratio,age±3 years old matching method,44 patients without Candida infection in the same time period and the same ward were selected as the control group.The clinical data of Candida infection in elderly patients were collected,and the types of pathogenic fungi,the types of specimen sources,and the drug susceptibility test of Candida drugs were collected.Multivariate logistic regression analysis was used to explore the risk factors of Candida infection in elderly patients.Results Among the 44 pa-tients with nosocomial Candida infection,the majority were Candida albicans,with 27 strains were detected,accounting for 61.36％.The main samples of Candida were midstream urine,accounting for 72.73％.The itraconazole resistance rate in Candida albicans was 14.81％.Candida glabrata was 12.50％resistant to both itraconazole and voriconazole.The resistance rate of Candida tropicalis to itraconazole,fluconazole and voriconazole reached 40％.All four Candida species were susceptible to 5-fluorocytosine.No drug-resistant strains found in nearly smooth Candida.The results of univariate a-nalysis showed that there were statistically significant differences in diabetes,bacterial infection,invasive operation,use of≥2 kinds of antibiotics,duration of treatment≥1week,length of hospital stay and albumin in the infection group compared with the control group(P＜0.05).The results of multivariate logistic regression analysis showed that the independent risk factors for Candida infection in elderly patients were co-infection with bacterial infection,invasive operation,use of≥2 kinds of antibiotics,duration of treatment ≥1 week,length of hospitalization＞14 days,and albumin≤35 g/L(P＜0.05).Conclusion Candida albicans is the most common pathogen of nosocomial fungal infection in elderly patients.Can-dida showed varying degrees of resistance to azole and polyene antifungals.Infection with Candida in elderly patients is af-fected by many factors,so appropriate prevention and control measures should be taken to avoid nosocomial fungal infection.
万方数据
维普
