Suboptimal voriconazole plasma concentration during cryptococcal treatment:a case report
Cryptococcal infection is mainly caused by Cryptococcus neoformans,which can attack human tissues such as lung and central nervous system.This paper presents a case of cryptococcal infection in a patient with a high probability of being a rapid metabolizer of CYP2C19,who experienced successive issues of fluconazole resistance and suboptimal voricon-azole plasma concentration during the course of anti-infective treatment.Timely adjustment to a combined therapeutic regi-men of amphotericin B liposome and flucytosine ultimately led to clinical improvement.This case analysis aims to provide valuable insights and reference for clinical practice.
Cryptococcusdrug resistanceblood drug concentrationvoriconazoleCYP2C19 rapid metabolizer
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