Cryptococcal infection is mainly caused by Cryptococcus neoformans,which can attack human tissues such as lung and central nervous system.This paper presents a case of cryptococcal infection in a patient with a high probability of being a rapid metabolizer of CYP2C19,who experienced successive issues of fluconazole resistance and suboptimal voricon-azole plasma concentration during the course of anti-infective treatment.Timely adjustment to a combined therapeutic regi-men of amphotericin B liposome and flucytosine ultimately led to clinical improvement.This case analysis aims to provide valuable insights and reference for clinical practice.
关键词
隐球菌/耐药/血药浓度/伏立康唑/CYP2C19快代谢型
Key words
Cryptococcus/drug resistance/blood drug concentration/voriconazole/CYP2C19 rapid metabolizer
维普
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