Analysis of clinical and laboratory characteristics of 55 cases of candidemia
Objective To investigate the epidemiology,clinical characteristics,pathogen distribution,antifungal suscepti-bility and outcome of candidemia,so as to provide basis for clinical pathogenic diagnosis of candidaemia and rational use of antifungal drugs.Methods Clinical and laboratory data of patients with candidemia in the first affiliated hospital of Yangtze university from January 2019 to December 2022 were retrospectively analyzed.The fungal species,time to positive,speci-men delivery department and antifungal susceptibility test were analyzed.Results A total of 55 patients with candidaemia were collected.The first three Candida isolates were Candida parapsilosis(16 strains,29.1％),Candida albicans(16 strains,29.1％),Candida tropicalis(14 strains,25.5％)respectively.The time to positive of Candida tropicalis was the shortest(21.1±7.8)h.The top three departments of candidemia was the intensive care unit(ICU)with 18 cases(32.7％),hematology with 11 cases(20.0％)and hepatobiliary surgery with 10 cases(18.2％).Abdominal infection was the most common source of infection.All Candida were sensitive to 5-fluorocytosine and showed varying degrees of resistance to other antifungal drugs,especially Candida tropicalis had the highest resistant rate to azoles.The 30-day mortality rate of patients with candidaemia was 32.7％.Ages,malignancy,ICU admission,septic shock,surgical operation,high level of procalcitonin and combined bacterial bloodstream infection were risk factors for 30-day mortality.Conclusion Candidemia was predominantly caused by non-Candida albicans,and most strains were sensitive to some antifungal drugs,patients ac-companied by a variety of risk factors and severe underlying diseases had poor prognosis,which should attract sufficient at-tention of clinicians.
万方数据
维普
