Clinical characteristics and risk factors for mortality of patients with fungal bloodstream infection in a hos-pital from 2013 to 2022
Objective To investigate the pathogenic distribution and prognosis of patients with fungal bloodstream infec-tion,and analyze the related risk factors,so as to provide experience and basis for clinical diagnosis and treatment of fungal bloodstream infection.Method Patients with fungal bloodstream infection in Subei People's Hospital of Jiangsu Province from December 2013 to December 2022 were selected as the study objects,and the fungal distribution,antifungal sensitivity,related risk factors and prognosis of these cases were retrospectively analyzed.Results Among 195 cases of fungal blood-stream infection,133 were male,with an average age of 66 years.There were 62 female patients with an average age of 65 years.Candida albicans,Candida tropicalis and Candida glabrata accounted for 45.4％,16.9％and 15.3％of the 195 cases of fungal bloodstream infection,respectively.101 cases died,the mortality rate was 51.8％;The detection of Candida albicans in death patients was the highest(50.5％,51/101);univariate analysis showed that length of hospital stay,renal insufficiency,liver insufficiency ≥2 underlying diseases,ICU admission,mechanical ventilation,tracheal intubation,indent catheter,and carbapenyl drug use were associated with mortality(P＜0.05).The results of multivariate logistic binary re-gression analysis indicated that length of stay,≥2 underlying diseases and tracheal intubation were independent risk factors associated with mortality in patients with fungal bloodstream infection.Conclusion Hospital length of stay,≥2 kinds of underlying diseases and tracheal intubation were independent risk factors for mortality in fungal bloodstream infections.Candida albicans was the most seen isolate in fungal bloodstream infection,while Candida tropicalis and Candida glabrata showed lower sensitivity to azole antifungal agents.
fungiCandidabloodstream infectionclinical characteristicsrisk factors for mortality
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