目的 探究改良触头电离子联合药物封包治疗甲真菌病的临床应用研究.方法 纳入2021年11月—2023年11月期间顺德区乐从医院皮肤性病科收治的94例甲真菌病患者为研究对象.采用随机数表法分成两组,其中对照组口服伊曲康唑治疗(n=47);研究组在口服伊曲康唑的基础上,增加局部改良触头电离子联合特比萘芬封包治疗(n=47).分析两组患者的临床疗效、甲真菌病临床评分指数(scoring clinical index of onychomycosis,SCIO)、甲真菌病严重程度指数(onych-omycosis severity index,OSI)、真菌清除率、不良反应情况.结果 ①研究组患者的疗效为97.87％,高于对照组的疗效82.98％(P<0.05).②研究组真菌清除率为95.74％,高于对照组真菌清除率80.85％(P<0.05).③治疗6个月后,研究组SCIO、OSI评分低于对照组(P<0.05).结论 改良触头电离子联合药物封包在甲真菌病中能够提高临床治疗效果和真菌清除率.
Clinical application of modified contact ion combined with drug encapsulation for onychomycosis
Objective To explore the clinical application of improved contact ion combined with drug encapsulation in the treatment of onychomycosis.Methods This study included 94 cases of onychomycosis patients admitted to dermatology and venereology Department of Lecong Hospital,Shunde District from November 2021 to November 2023.They were divided into two groups by random number table method.Control group was treated withoralitraconazole (n=47).On the basis of oral itraconazole,the study group added local modified contact ion combined with terbinafine encapsulation therapy (n=47).Clinical efficacy,scoring clinical index of onychomycosis (SCIO score) and onychomycosis severity index (OSI score),fun-gal clearance,adverse reactionsof the two groups were analyzed.Results (1) The therapeutic effective rate of the study group(97.87％)was higher than that of the control group (82.98％)(P<0.05).(2) The fungal clearance rate of the study group was 95.74％,which was higher than that of the control group (80.85％) (P<0.05).(3) After 6 months of treat-ment,SCIO and OSI scores of the study group were lower than those of the control group (P<0.05).(4) The adverse re-actions in the study group were lower than those in the control group (P>0.05).Conclusion Improved contact ion com-bined with drug encapsulation can improve the clinical therapeutic effect and fungal clearance in onychomycosis.
万方数据
维普
