A 75-year-old male patient was admitted to the hospital presenting with 'recurrent cough and sputum production for 1 year,exacerbation for 1 month,and hemoptysis for 1 day.' One day prior to admission,the patient experienced sudden episodes of coughing up blood six times,with a total volume of approximately 500 mL,accompanied by a cough producing yellow sputum and shortness of breath.Bronchoalveolar lavage fluid (BALF) analysis by conventional etiology testing and metagenomic next-generation sequencing revealed Aspergillus fumigatus and Aspergillus flavus.Culture and antimicrobial susceptibility testing of the BALF confirmed Aspergillus fumigatus.The pathological diagnosis from the right lung biopsy indicated poorly differentiated squamous cell carcinoma.The final diagnosis was lung cancer combined with pulmonary asper-gillosis.Initial treatment involved intravenous voriconazole for antifungal therapy,followed by paclitaxel plus carboplatin and sintilimab injection for chemotherapy and immunotherapy.Subsequently,maintenance therapy with sintilimab injection was initiated.The patient is currently in stable condition.
维普
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