摘要
[目的]研究手机使用与听神经瘤发病风险的关系,探讨手机使用的安全性.[方法] 在线检索文献资料,分析手机使用与听神经瘤发病风险关系的病例对照研究,采用随机效应模型计算合并OR值,Meta回归筛选异质性影响因素,进行亚组分析.[结果] 共纳入8篇文献,包括1 527例听神经瘤患者和7 636例对照.各研究存在异质性,随机效应模型结果表明,手机使用、长期使用与听神经瘤发病风险均无统计学关联,合并OR值分别为0.93(95%CI:0.75～1.16)和1.35(95%CI:0.81～2.25).经Meta回归分析,以地区为异质性影响因素,做亚组分析.两亚组使用手机对听神经瘤的风险均未发现有显著影响,合并OR值分别为0.88(95%CI:0.77～1.00)和1.09(95%CI:O.80～1.51).长期使用手机使听神经瘤发病风险增加,合并OR值分别为1.39(95%CI:1.12～1.73)和1.94(95%CI:1.30～2.89).[结论] 手机使用与听神经瘤的关联尚不能定论,但可能存在剂量一反应关系,需要进一步的研究.
Abstract
[ Purpose] To investigate the relationship between mobile phone use and dsk for acoustic neuroma and to evaluate the adverse effect of cell phone use. [Methods] According to the online search of relevant case-control study on the relationship between mobile phone use and the risk for acoustic neuroma, random effects estimation was used to assess pooled odds ratios. Meta-regression and subgroup analysis were used for heterogeneity analysis. [Results] A total of 8 studies were included in this Meta-analysis, including 1 527 cases with acoustic neuroma and 7 636 controls. Use or frequently use of a cellular phone was not associated with acoustic neuroma, with pooled odds ratio 0.93 (95％Cl :0.75～1.16) and 1.35 (95％CI :0.81～2.25) respectively. Area was selected as a factor of heterogeneity according to Meta-regression, and the included 8 studies were separated into two subgroups. No significant associations were found between regular cell phone use and risk of acoustic neuroma in two subgroups, with pooled odds ratio 0.88(95％Cl:0.77～1.00) and 1.09(95％Cl:0.80～1.51).Elevated ORs were observed in two subgroups for long-term mobile phone use, with pooled odds ratio 1.39(95％Cl:1.12～1.73) and 1.94(95％CI:1.30～2.89) respectively. [Conclusion] The relationship between mobile phone use and acoustic neuroma couldn't be concluded. A potential dose-response relationship between cell phone use and acoustic neuroma might exist. Further studies are needed to evaluate the side effect of cell phone use.
NETL
NSTL
维普
万方数据