摘要
[目的]分析2006-2020年浙江省嘉善县死亡风险居前3位的肺癌、肝癌和胃癌的生存情况.[方法]以浙江省嘉善县2006年1月1日至2020年12月31日期间报告的肺癌、肝癌、胃癌病例为研究对象,分别计算2006-2010年、2011-2015年和2016-2020年3个时期分性别和年龄的5年观察生存率、相对生存率及标化相对生存率.采用寿命表法和Ederer Ⅱ法分别计算观察生存率和相对生存率,采用国际癌症生存标准进行年龄标化.采用Joinpoint软件计算平均年度变化百分比(average annual percentage change,AAPC),分析各类生存率在2006-2020年间的变化趋势.[结果]肺癌、肝癌和胃癌5年相对生存率分别从2006-2010年的8.1％、4.8％和23.2％提升至2016-2020年的36.0％、17.6％和48.2％,均呈逐年递增趋势(肺癌AAPC=14.4％,肝癌AAPC=11.4％,胃癌AAPC=6.4％,P均＜0.05).除女性肝癌外,3类恶性肿瘤5年相对生存率在男性和女性中均呈逐年递增趋势(P均＜0.05).0～64岁和65岁及以上年龄组的3类恶性肿瘤5年相对生存率均呈明显上升趋势(P均＜0.05),其中肺癌、肝癌在0～64岁年龄组的增幅更大,胃癌则是65岁及以上年龄组的增幅更大.[结论]浙江省嘉善县死亡风险居前3位的恶性肿瘤的5年生存率在2006-2020年期间均明显上升,恶性肿瘤的防治效果显著,但在不同人群间恶性肿瘤生存率差异显著,应进行针对性干预.
Abstract
[Purpose]To analyze the survival of lung cancer,liver cancer and stomach cancer in Jiashan County,Zhejiang Province from 2006 to 2020.[Methods]From January 1,2006 to De-cember 31,2020,new cases of lung cancer,liver cancer and stomach cancer were collected in Jiashan County,Zhejiang Province.The 5-year observed survival rate(OSR),relative survival rate(RSR)and age-standardized relative survival rate(ARSR)by sex and age were calculated from 2006-2010,2011-2015 and 2016-2020.The observed and relative survivals were calculated using the lifetime table and Ederer Ⅱ methods,respectively,and age standardized using the Inter-national Cancer Survival Standard.Joinpoint software was utilized to compute the average annual percentage change(AAPC)for analyzing trends in various survival rates from 2006 to 2020.[Re-sults]The 5-year RSR of lung cancer,liver cancer and stomach cancer increased from 8.1％,4.8％and 23.2％(2006-2010)to 36.0％,17.6％and 48.2％(2016-2020),showing an increasing trend(AAPC=14.4％,AAPC=11.4％,AAPC=6.4％,respectively,all P＜0.05).Accordingly,the 5-year RSR of three types of malignant tumors showed an increasing trend in both men and women(all P＜0.05)except liver cancer in women(P＞0.05).The 5-year RSR of three types of malignant tu-mors in the age groups of 0～64 and 65+years old showed a significant increasing trend(all P＜0.05).The increase of lung cancer and liver cancer was greater in the age group of 0～64 years old,and the increase of gastric cancer was greater in the age group of 65+years old.[Conclusion]The 5-year survival rates of the three types of malignant tumors with the highest mortality risk in Jiashan County,Zhejiang Province all increased significantly from 2006 to 2020,indicating that the pre-vention and treatment effect of malignant tumors is significant,but the survival rate of malignant tumors varied significantly among different populations,so targeted intervention should be carried out.
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