首页|The role of intestinal flora on tumorigenesis,progression,and the efficacy of PD-1/PD-L1 antibodies in colorectal cancer

The role of intestinal flora on tumorigenesis,progression,and the efficacy of PD-1/PD-L1 antibodies in colorectal cancer

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Intestinal flora affects the maturation of the host immune system,serves as a biomarker and efficacy predictor in the immunotherapy of several cancers,and has an important role in the development of colorectal cancer(CRC).Anti-PD-1/PD-L1 antibodies have shown satisfactory results in MSI-H/dMMR CRC but performed poorly in patients with MSS/pMMR CRC.In recent years an increasing number of studies have shown that intestinal flora has an important impact on anti-PD-1/PD-L1 antibody efficacy in CRC patients.Preclinical and clinical evidence have suggested that anti-PD-1/PD-L1 antibody efficacy can be improved by altering the composition of the intestinal flora in CRC.Herein,we summarize the studies related to the influence of intestinal flora on anti-PD-1/PD-L1 antibody efficacy in CRC and discuss the potential underlying mechanism(s).We have focused on the impact of the intestinal flora on the efficacy and safety of anti-PD-1/PD-L1 antibodies in CRC and how to better utilize the intestinal flora as an adjuvant to improve the efficacy of anti-PD-1/PD-L1 antibodies.In addition,we have provided a basis for the potential of the intestinal flora as a new treatment modality and indicator for determining patient prognosis.

Intestinal floraanti-PD-1/PD-L1 therapycolorectal cancerimmune checkpoint inhibitorCD8+ T cell

Sen Wang、Benling Xu、Yangyang Zhang、Guangyu Chen、Peng Zhao、Quanli Gao、Long Yuan

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Department of Gastrointestinal Surgery,Affiliated Cancer Hospital of Zhengzhou University,Zhengzhou 450003,China

Department of Immunotherapy,Affiliated Cancer Hospital of Zhengzhou University,Zhengzhou 450003,China

National Cancer Center Climbing FundProvincialministerial Coconstruction Project of Henan Province Science and Technology Key Point Tackling PlanHenan Provincial Scientific and Technological ProjectHenan Provincial Scientific and Technological Project

NCC201916B03SBGJ202102064222102310363222102310677

2024

10.20892/j.issn.2095-3941.2023.0376

癌症生物学与医学(英文版)
中国抗癌协会

癌症生物学与医学(英文版)

CSTPCD
影响因子：1.07
ISSN：2095-3941
年,卷(期)：2024.21(1)
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