首页|Development of small molecule drugs targeting immune checkpoints
Development of small molecule drugs targeting immune checkpoints
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NETL
NSTL
万方数据
Immune checkpoint inhibitors(ICIs)are used to relieve and refuel anti-tumor immunity by blocking the interaction,transcription,and translation of co-inhibitory immune checkpoints or degrading co-inhibitory immune checkpoints.Thousands of small molecule drugs or biological materials,especially antibody-based ICIs,are actively being studied and antibodies are currently widely used.Limitations,such as anti-tumor efficacy,poor membrane permeability,and unneglected tolerance issues of antibody-based ICIs,remain evident but are thought to be overcome by small molecule drugs.Recent structural studies have broadened the scope of candidate immune checkpoint molecules,as well as innovative chemical inhibitors.By way of comparison,small molecule drug-based ICIs represent superior oral bioavailability and favorable pharmacokinetic features.Several ongoing clinical trials are exploring the synergetic effect of ICIs and other therapeutic strategies based on multiple ICI functions,including immune regulation,anti-angiogenesis,and cell cycle regulation.In this review we summarized the current progression of small molecule ICIs and the mechanism underlying immune checkpoint proteins,which will lay the foundation for further exploration.
Immune checkpointssmall molecule drugsprogrammed death protein 1CD47signal-regulatory protein α
Luoyi Chen、Xinchen Zhao、Xiaowei Liu、Yujie Ouyang、Chuan Xu、Ying Shi
展开 >
Department of Oncology,Sichuan Academy of Medical Sciences,Sichuan Provincial People's Hospital,School of Medicine,University of Electronic Science and Technology of China,Chengdu 610054,China
Institute for Breast Health Medicine,State Key Laboratory of Biotherapy,West China Hospital,Sichuan University,Chengdu 610041,China
Acupuncture and Massage College,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China
国家自然科学基金国家自然科学基金Provincial Cooperation Project of Science and Technology Department of Sichuan Province国家重点研发计划
NETL
NSTL
万方数据
