首页|Complex role of neutrophils in the tumor microenvironment:an avenue for novel immunotherapies

Complex role of neutrophils in the tumor microenvironment:an avenue for novel immunotherapies

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Neutrophils,which originate from the bone marrow and are characterized by a segmented nucleus and a brief lifespan,have a crucial role in the body's defense against infections and acute inflammation.Recent research has uncovered the complex roles of neutrophils as regulators in tumorigenesis,during which neutrophils exhibit a dualistic nature that promotes or inhibits tumor progression.This adaptability is pivotal within the tumor microenvironment(TME).In this review,we provide a comprehensive characterization of neutrophil plasticity and heterogeneity,aiming to illuminate current research findings and discuss potential therapeutic avenues.By delineating the intricate interplay of neutrophils in the TME,this review further underscores the urgent need to understand the dual functions of neutrophils with particular emphasis on the anti-tumor effects to facilitate the development of effective therapeutic strategies against cancer.

Neutrophilplasticitytumor microenvironmentimmunotherapy

Mao Zhang、Haokai Qin、Yingcheng Wu、Qiang Gao

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Department of Liver Surgery and Transplantation,Liver Cancer Institute and Zhongshan Hospital,State Key Laboratory of Genetic Engineering,Human Phenome Institute,Fudan University,Shanghai 200433,China

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaResearch Projects from the Science and Technology Commission of Shanghai MunicipalityResearch Projects from the Science and Technology Commission of Shanghai MunicipalityResearch Projects from the Science and Technology Commission of Shanghai MunicipalityChina National Postdoctoral Program for Innovative TalentsChina Postdoctoral Science Foundation

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2024

10.20892/j.issn.2095-3941.2024.0192

癌症生物学与医学(英文版)
中国抗癌协会

癌症生物学与医学(英文版)

CSTPCD
影响因子：1.07
ISSN：2095-3941
年,卷(期)：2024.21(10)