Ubiquitination in osteosarcoma:unveiling the impact on cell biology and therapeutic strategies

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外文摘要：Ubiquitination,a multifaceted post-translational modification,regulates protein function,degradation,and gene expression.The pivotal role of ubiquitination in the pathogenesis and progression of cancer,including colorectal,breast,and liver cancer,is well-established.Osteosarcoma,an aggressive bone tumor predominantly affecting adolescents,also exhibits dysregulation of the ubiquitination system,encompassing both ubiquitination and deubiquitination processes.This dysregulation is now recognized as a key driver of osteosarcoma development,progression,and chemoresistance.This review highlights recent progress in elucidating how ubiquitination modulates tumor behavior across signaling pathways.We then focus on the mechanisms by which ubiquitination influences osteosarcoma cell function.Finally,we discuss the potential for targeting the ubiquitin-proteasome system in osteosarcoma therapy.By unraveling the impact of ubiquitination on osteosarcoma cell physiology,we aim to facilitate the development of novel strategies for prognosis,staging,treatment,and overcoming chemoresistance.

外文关键词：

Ubiquitinationosteosarcomacancer developmenttherapeutic target

作者：

Jianlin Shen、Yue Lai、Yanjiao Wu、Xuan Lin、Cheng Zhang、Huan Liu

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作者单位：

Department of Orthopedics,Affiliated Hospital of Putian University,Putian 351100,China

Central Laboratory,Affiliated Hospital of Putian University,Putian 351100,China

Department of Orthopedics,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524000,China

Shunde Hospital,Southern Medical University(The First People's Hospital of Shunde),Foshan 528000,China

Department of Environmental and Biological Engineering,Putian University,Putian 351100,China

Department of Trauma Center,Zhongda Hospital,Southeast University,Nanjing 210000,China

Department of Orthopedics,The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University,Luzhou 646000,China

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基金：

Sichuan Provincial Central Leading Local Science and Technology Development Special ProjectNational Natural Science Foundation of ChinaGuangdong Basic and Applied Basic Research Foundation

项目编号：

2023ZYD0072823017852019A1515111078

出版年：

2024

DOI：

10.20892/j.issn.2095-3941.2024.0231

癌症生物学与医学(英文版)

中国抗癌协会

癌症生物学与医学(英文版)

CSTPCD

影响因子：1.07

ISSN：2095-3941

年,卷(期)：2024.21(10)