首页|Intricate roles of estrogen and estrogen receptors in digestive system cancers:a systematic review
Intricate roles of estrogen and estrogen receptors in digestive system cancers:a systematic review
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Gender disparities are evident across different types of digestive system cancers,which are typically characterized by a lower incidence and mortality rate in females compared to males.This finding suggests a potential protective role of female steroid hormones,particularly estrogen,in the development of these cancers.Estrogen is a well-known sex hormone that not only regulates the reproductive system but also exerts diverse effects on non-reproductive organs mediated through interactions with estrogen receptors(ERs),including the classic(ERα and ERβ)and non-traditional ERs[G protein-coupled estrogen receptor(GPER)].Recent advances have contributed to our comprehension of the mechanisms underlying ERs in digestive system cancers.In this comprehensive review we summarize the current understanding of the intricate roles played by estrogen and ERs in the major types of digestive system cancers,including hepatocellular,pancreatic,esophageal,gastric,and colorectal carcinoma.Furthermore,we discuss the potential molecular mechanisms underlying ERα,ERβ,and GPER effects,and propose perspectives on innovative therapies and preventive measures targeting the pathways regulated by estrogen and ERs.The roles of estrogen and ERs in digestive system cancers are complicated and depend on the cell type and tissue involved.Additionally,deciphering the intricate roles of estrogen,ERs,and the associated signaling pathways may guide the discovery of novel and tailored therapeutic and preventive strategies for digestive system cancers,eventually improving the care and clinical outcomes for the substantial number of individuals worldwide affected by these malignancies.
Estrogenestrogen receptorcancerdigestive system cancersgender disparity
Xiaoning Gan、Guanqi Dai、Yonghao Li、Lin Xu、Guolong Liu
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Department of Medical Oncology,The Second Affiliated Hospital,School of Medicine,South China University of Technology,Guangzhou 510180,China
Department of Physiology,Michigan State University,East Lansing 48824,USA
Department of Radiation Oncology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China
Project of Scientific and Technologic Bureau of Guangzhou CityKey Project of Scientific and Technologic Bureau of Guangzhou City
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