胃神经内分泌癌的研究进展
Research progress in gastric neuroendocrine carcinoma
周凯 1王安强 1吴艳 2李忠武 2步召德1
作者信息
- 1. 北京大学肿瘤医院暨北京市肿瘤防治研究所胃肠肿瘤中心,恶性肿瘤发病机制及转化研究教育部重点实验室(北京市 100142)
- 2. 北京大学肿瘤医院暨北京市肿瘤防治研究所病理科(北京市100142)
- 折叠
摘要
胃神经内分泌癌(gastric neuroendocrine carcinoma,G-NEC)发病率极低.患者确诊时多数已处于晚期,且通常比胃腺癌更具侵袭性,更易发生脉管癌栓、神经侵犯及术后肝转移.目前治疗方法有限且尚未形成统一的规范化方案,导致患者预后较差.随着人类G-NEC的基因组图谱的构建,识别出MYC作为疾病的关键驱动因子,开发小鼠模型来研究其分子和细胞特征,通过大规模的遗传和药理筛选,为理解G-NEC的生物学特性及治疗提供了新的思路.目前对于G-NEC的发病机制、分子生物学特征、临床病理特点及诊治仍缺乏足够的认识,为进一步提升对该疾病的系统认知,本文对国内外文献进行系统总结,旨在为G-NEC的大样本临床基础转化研究提供系统的理论支持.
Abstract
Gastric neuroendocrine carcinoma(G-NEC)is a rare malignancy,constituting a small percentage of all gastric cancers.G-NEC is typically diagnosed at advanced stages and exhibits more significant invasiveness than gastric adenocarcinoma,with a higher propensity for vascular invasion,nerve infiltration,and postoperative liver metastasis.Current treatment options are limited and lack standardization,lead-ing to a poor prognosis.Recent studies have elucidated the genomic landscape of human G-NEC,identifying MYC as a pivotal oncogenic driver and establishing a murine model to investigate its molecular and cellular characteristics.Genetic and pharmacological screening has yielded novel insights into the biology and therapeutic approaches for G-NEC.Currently,there is a lack of comprehensive knowledge regard-ing the pathogenesis,molecular biological characteristics,clinical pathology,and diagnosis and treatment of G-NEC.To advance the system-atic comprehension of this condition,this article aims to systematically review domestic and international literature,with the goal of offering theoretical support for large-scale clinical translational research on G-NEC.
关键词
胃神经内分泌癌/发病机制/分子生物学特征/诊疗Key words
gastric neuroendocrine carcinoma(G-NEC)/pathogenesis/molecular biological characteristics/diagnosis and treatment引用本文复制引用
出版年
2024
NETL
NSTL
万方数据