乳酸化调控肿瘤发生发展的研究现状
Current research status of lactylation in regulating tumor occurrence and development
张博兴 1王树楷 1杨好 1宋亮2
作者信息
- 1. 陕西中医药大学第二临床医学院(陕西省咸阳市 712046)
- 2. 陕西中医药大学医学科研实验中心
- 折叠
摘要
乳酸化是一种新颖的依赖乳酸的蛋白质翻译后修饰方式,其可以通过将乳酰基与蛋白质赖氨酸残基共价耦联,改变蛋白质结构和功能,调控基因表达,从而参与细胞代谢和生长过程.近期研究发现肿瘤组织中的乳酸化能够通过调控细胞内信号转导、基因表达和蛋白功能,进而影响肿瘤发生发展.本文综述乳酸化的发现过程及其在肿瘤中的研究进展,旨在为肿瘤的预防和治疗提供新思路.
Abstract
Lactylation is a novel lactate-dependent post-translational modification that can alter the structure and function of proteins by covalently coupling lactoyl groups to lysine residues.Therefore,gene expression is regulated and lactylation participates in cellular metabolic and growth processes.Recent studies have shown that lactylation in tumor tissues can affect tumor occurrence and development by regu-lating intracellular signal transduction,gene expression,and protein function.This review summarizes the discovery process of lactylation and recent research progress in tumors,providing novel insights into their prevention and treatment.
关键词
乳酸化/肿瘤/翻译后修饰Key words
lactylation/tumor/post-translational modification引用本文复制引用
基金项目
陕西省"特支计划"区域发展人才项目(2017)
陕西省留学人员科技活动择优资助项目(2018046)
陕西省高等学校青年创新团队项目(2023)
出版年
2024
NETL
NSTL
万方数据