Research progress of induction immunotherapy before radiotherapy in unresectable stage Ⅲ non-small cell lung cancer
Lung cancer is the leading cause of cancer-related deaths worldwide,and non-small cell lung cancer(NSCLC)is the most common type.Because more than one-third of NSCLC patients are diagnosed at stage Ⅲ,most of these tumors are unresectable.Chemoradiother-apy(CRT)is the standard treatment for unresectable stage Ⅲ NSCLC;however,its curative efficacy is poor.Compared with simple CRT,the survival rate of patients with unresectable stage Ⅲ NSCLC following consolidated immunotherapy after CRT has significantly improved ow-ing to the emergence of immune checkpoint inhibitors.However,a subset of patients do not benefit from consolidated immunotherapy.Based on the effectiveness of induction immunotherapy in resectable stage Ⅲ NSCLC,studies have been conducted to extend its application in unresectable stage Ⅲ NSCLC.This article reviews the mechanism of action,recent advancements in clinical research,and cycle of induc-tion immunotherapy before radiotherapy in unresectable stage Ⅲ NSCLC to provide a reference for clinical treatment of unresectable stageⅢ NSCLC.
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