髓源性抑制细胞在多发性骨髓瘤中的研究进展
Research progress on myeloid-derived suppressor cells in multiple myeloma
汤斌 1彭晓欢 1熊皓 1刘佳 1朱小凤 1李莉娟 1张连生1
作者信息
- 1. 兰州大学第二医院血液科(兰州市 730000)
- 折叠
摘要
多发性骨髓瘤(multiple myeloma,MM)是浆细胞恶性增殖性疾病,目前为血液系统第二大肿瘤.虽然蛋白酶体抑制剂和免疫治疗方案的应用改善了MM患者的预后,但大多数仍然无法被治愈,主要是因为MM细胞最终产生耐药.髓源性抑制细胞(myeloid-derived suppressor cells,MDSCs)是骨髓中髓系祖细胞分化受阻而形成的具有显著抑制T细胞免疫应答功能的一群异质性细胞,通过介导免疫抑制性作用促进MM的发展.MDSCs还刺激MM细胞增殖,诱导MM耐药和转移.本文综述了MD-SCs在MM发生、发展中表现的多种机制,并探讨针对MDSCs的治疗策略在MM中的可行性及挑战,以期为MM治疗提供参考.
Abstract
Multiple myeloma(MM)is a malignant proliferative disease of plasma cells,ranking as the second most common hematologic tu-mor.Although the use of proteasome inhibitors and immunotherapeutic regimens has improved the prognosis of patients with MM,it re-mains incurable in most patients,mainly because of the eventual development of drug resistance in MM cells.Myeloid-derived suppressor cells(MDSCs)are a heterogeneous group of cells causing significant suppression of the T-cell immune response.They arise from bone mar-row myeloid progenitor cells that are blocked from differentiation and promote MM development by resisting immune destruction.Recent studies indicate that MDSCs stimulate MM cell proliferation,inducing drug resistance and metastasis.In this paper,we review multiple mechanisms exhibited by MDSCs in MM pathogenesis and discuss the feasibility and challenges of current therapeutic strategies targeting MDSCs,aiming to provide pertinent references regarding MM treatment.
关键词
多发性骨髓瘤/髓源性抑制性细胞/肿瘤微环境/逆转免疫抑制/血管生成Key words
multiple myeloma(MM)/myeloid-derived suppressor cells(MDSCs)/tumor microenvironment/reverse of immunosuppres-sion/angiogenesis引用本文复制引用
出版年
2024
NETL
NSTL
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