免疫治疗在胃癌中的应用研究进展
Progress on the application of immunotherapy in gastric cancer
熊德君 1丁晓凌 2周晓荣1
作者信息
- 1. 南通大学医学院免疫系教研室(江苏省南通市 226001)
- 2. 南通大学附属医院消化内科
- 折叠
摘要
胃癌是全球最常见的恶性肿瘤之一,由于胃癌筛查率低和早期症状轻微,多数患者在晚期才被确诊,影响预后.近年来,随着研究深入,胃癌的免疫治疗取得显著进展,尤其对不可切除和转移性病例效果显著,使其成为继手术、化疗、放疗和靶向治疗后的有效治疗方法.免疫治疗通过人为调控免疫系统生效,包括过继细胞疗法、免疫检查点抑制剂和肿瘤疫苗等.目前,免疫治疗虽然前景广阔,但在临床应用中仍面临诸多挑战和问题.本文就胃癌免疫治疗的临床应用以及存在的问题进行综述.
Abstract
Gastric cancer is among the most common malignant tumors worldwide.Due to its subtle early symptoms and suboptimal screening rates,a significant proportion of patients are diagnosed with advanced-stage gastric cancer,which adversely influences patient prognosis.In recent years,with the advancement of research,immunotherapy for gastric cancer has made significant strides,demonstrating particularly remarkable efficacy in cases of unresectable and metastatic gastric cancer.This has established it as an effective treatment method following surgery,chemotherapy,radiotherapy,and targeted therapy.Immunotherapy involves artificially modulating the immune system using strategies such as adoptive cell therapy,immune checkpoint inhibitors,and tumor vaccines.Although immunotherapy has broad prospects,it faces many challenges and problems in clinical application.This review delineates the clinical application of immunother-apy in gastric cancer and discusses the extant challenges therein.
关键词
胃癌/免疫治疗/过继细胞疗法/免疫检查点抑制剂/肿瘤疫苗Key words
gastric cancer/immunotherapy/adoptive cell therapy/immune checkpoint inhibitors/tumor vaccines引用本文复制引用
基金项目
国家自然科学基金面上项目(82172931)
国家自然科学基金面上项目(32170915)
出版年
2024
NETL
NSTL
万方数据