手术方式对原发中枢神经系统淋巴瘤患者疗效和安全性的影响
Impact of surgical approach on the efficacy and safety of patients with primary central nervous system lymphoma
代香萍 1薛磊 2许倩文 2胡艳 3陈元禄 2王兴兵1
作者信息
- 1. 安徽医科大学附属省立医院血液科(合肥市 230001);中国科学技术大学附属第一医院(安徽省立医院)血液科
- 2. 中国科学技术大学附属第一医院(安徽省立医院)血液科
- 3. 合肥京东方医院血液科
- 折叠
摘要
目的:探讨不同手术方式对原发中枢神经系统淋巴瘤(primary central nervous system lymphoma,PCNSL)患者疗效和安全性的影响.方法:回顾性分析 2012年 7月至 2023年 5月中国科学技术大学附属第一医院(安徽省立医院)收治的 130例PCNSL患者的临床资料,根据手术方式分为切除组和活检组,比较两组的安全性及疗效,包括化疗后的客观缓解率(objective re-sponse rate,ORR)、总生存期(overall survival,OS)和无进展生存期(progression-free survival,PFS).结果:切除组的ORR、2年OS率、2年PFS率与活检组比较无统计学差异(ORR:63.2%vs.62.8%;2年OS率:68.6%vs.73.7%;2年PFS率:35.2%vs.40.7%,P>0.05),切除组的术后并发症发生率高于活检组(29.3%vs.11.4%,P=0.04).两组住院时间无统计学差异,但活检组费用较少(P<0.01).结论:对PCNSL患者,接受活检和切除的疗效相当,但与切除相比,活检的安全性较好,且住院费用更少.
Abstract
Objective:To investigate the effects of different surgical approaches on the efficacy and safety of patients with primary central nervous system lymphoma(PCNSL).Methods:The clinical data of 130 PCNSL patients admitted to The First Affiliated Hospital of University of Science and Tecnology of China between July 2012 and May 2023 were retrospectively analyzed.Patients were assigned into resection and biopsy groups according to the surgical approach.The safety and efficacy of the two groups were compared,including the objective re-sponse rate(ORR),overall survival(OS),and progression-free survival(PFS)after chemotherapy.Results:ORR and 2-year OS and PFS rates of the resection group were not significantly different from those of the biopsy group(ORR:63.2%vs.62.8%;2-year OS rate:68.6%vs.73.7%;2-year PFS rate:35.2%vs.40.7%,all P>0.05).The incidence of postoperative complications was significantly higher in the resection group than in the biopsy group(29.3%vs.11.4%,P=0.04).The difference in the length of hospitalization between the two groups was not statistic-ally significant.Treatment of the biopsy group was less expensive(P<0.01).Conclusions:In patients with PCNSL,biopsy and resection had comparable efficacy;however,the safety profile was better,and hospitalization was less costly in biopsy than in resection.
关键词
原发中枢神经系统淋巴瘤/手术治疗/疗效/安全性Key words
primary central nervous system lymphoma(PCNSL)/surgical therapy/efficacy/safety引用本文复制引用
基金项目
国家自然科学基金项目(82170221)
安徽省重点研究与开发计划项目(2022e07020022)
出版年
2024
NETL
NSTL
万方数据