首页|肿瘤源性外泌体在肺癌微环境中的免疫编辑作用研究进展

肿瘤源性外泌体在肺癌微环境中的免疫编辑作用研究进展

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外泌体是一种由免疫细胞、干细胞和肿瘤细胞等多种细胞分泌的纳米级颗粒,富含多种生物活性物质并携带肿瘤信息,介导细胞间物质和信息传递,参与调控多种病生理过程并参与肿瘤微环境重塑.不同肿瘤细胞分泌的外泌体具有亲本细胞特异性,其内含有各种参与调节免疫的正向及负向因子,几乎能够与所有类型免疫细胞相互作用.癌症免疫编辑是免疫系统调控肿瘤发展的过程,包括消除、平衡和逃逸 3个阶段.肿瘤源性外泌体(tumor-derived exosomes,TEXs)既可以促进抗肿瘤免疫,也可以抑制免疫细胞的抗肿瘤活性:免疫消除阶段,TEXs通过携带的大量肿瘤抗原等信息,促进免疫细胞成熟发育并触发抗肿瘤免疫应答;免疫平衡阶段,TEXs参与肿瘤抵抗,使得其与适应性免疫处于动态平衡;免疫抑制阶段,TEXs通过扮演肿瘤的有效载体将生物活性物质从肿瘤部位播散至远处,参与免疫细胞介导的免疫逃逸.本文就TEXs在调节肺癌免疫微环境中的免疫编辑作用做一综述,为抗肿瘤治疗提供新思路.
Research progress on immunoediting role of tumor-derived exosomes in the microen-vironment of lung cancer
Exosomes are nanoscale particles secreted by various cells,including immune,stem,and tumor cells.They are enriched with bio-active substances that transport tumor information,mediate intercellular communication,and regulate multiple physiological processes and tumor microenvironment(TME)remodeling.Exosomes secreted by different tumor cell types exhibit cell-specific characteristics,contain various factors involved in immune regulation,and can interact with all types of immune cells.Cancer immunoediting is a process in which the immune system can both constrain and promote tumor development,involving three phases:elimination,equilibrium,and escape.Tu-mor-derived exosomes play diverse roles during these stages,both promoting anti-tumor immunity and inhibiting the anti-tumor activity of immune cells.Collectively,understanding the immunoediting role of exhausted T cells(TEXs)in regulating the immune microenvironment in lung cancer provides novel insights into antitumor therapy.

exosomelung cancerimmunoeditingimmune microenvironment

陈钦、王静、蒋日成、秦建文

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天津市胸科医院呼吸与危重症医学科(天津市 300050)

天津医科大学肿瘤医院肺部肿瘤内科,国家恶性肿瘤临床医学研究中心,天津市"肿瘤防治"重点实验室,天津肺癌研究中心

外泌体 肺肿瘤 免疫编辑 免疫微环境

Tianjin Key Medical Discipline(Specialty)Construction ProjectTianjin Key Medical Discipline(Specialty)Construction Project国家自然科学基金项目天津市医学重点学科(专科)建设项目内科学(呼吸病学)&&天津市卫生健康科技项目

TJYXZDXK-049ATJYXZDXK-010A82172620TJYXZDXK-049ATJYXZDXK-010ATJWJ2022QN066

2024

10.12354/j.issn.1000-8179.2024.20231146

中国肿瘤临床
中国抗癌协会

中国肿瘤临床

CSTPCD北大核心
影响因子：1.32
ISSN：1000-8179
年,卷(期)：2024.51(10)