首页|白细胞介素-6在肿瘤免疫检查点抑制剂治疗中的作用研究进展

白细胞介素-6在肿瘤免疫检查点抑制剂治疗中的作用研究进展

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免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)作为一种免疫疗法,在多种癌症的治疗中发挥着重要作用,同时,其可诱导多种免疫相关不良事件(immune-related adverse events,irAEs)的发生.白细胞介素-6(interleukin-6,IL-6)是一种重要的炎症因子,已被证明可通过多种机制促进癌症进展及影响ICIs的临床应用.本文就细胞因子IL-6如何调节免疫检查点的表达以及对免疫阻断疗法和irAEs的影响进行探讨,总结靶向IL-6信号转导对ICIs功效及irAEs治疗的作用.
Research progress on the role of interleukin-6 in tumor immune checkpoint inhibitor therapy
Immune checkpoint inhibitors(ICI),an immunotherapy,have an important role in the treatment of various cancers.However,ICIs induce several immune-related adverse events(irAEs).Interleukin(IL)-6 is an important inflammatory factor that promotes cancer progres-sion and modulates the clinical application of ICIs through various mechanisms.Herein,we postulate possible mechanisms that are involved in the ICI-regulatory effects mediated by the expression of the cytokine interleukin-6(IL-6),elucidate the effect of IL-6 on checkpoint-block-ade therapy and irAEs,and summarize the role of IL-6 signaling-targeted interventions in ICIs efficacy and irAEs management.

interleukin-6(IL-6)tumorimmune checkpoint inhibitors(ICIs)immune-related adverse events(irAEs)

朱玲玲、张亚妮、史婷婷、于晓辉、张久聪

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中国人民解放军联勤保障部队第九四〇医院消化内科(兰州市 730050)

甘肃中医药大学第一临床医学院

白细胞介素-6 肿瘤 免疫检查点抑制剂 免疫相关不良事件

中央高校优秀青年团队培育项目甘肃省科技计划项目中国人民解放军联勤保障部队第九四〇医院院内科研重点项目院内科研拔尖项目

100145120121JR7RA0172021yxky0792021yxky002

2024

中国肿瘤临床
中国抗癌协会

中国肿瘤临床

CSTPCD北大核心
影响因子:1.32
ISSN:1000-8179
年,卷(期):2024.51(11)