首页|三阴性乳腺癌的化疗疗效与肿瘤微环境相关性的研究进展

三阴性乳腺癌的化疗疗效与肿瘤微环境相关性的研究进展

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三阴性乳腺癌(triple-negative breast cancer,TNBC)明显的肿瘤异质性和多样的肿瘤微环境(tumor microenvironment,TME)特征加大了其研究和治疗的难度.化疗是TNBC治疗的重要手段之一,治疗后疗效预测及化疗耐药仍是临床亟待解决的难题,其中TME的变化是一个主要的原因.了解肿瘤微环境在其中起到的促进作用对这一困境的突破至关重要.本文综合多组学研究的结论,探讨了TNBC临床疗效及化疗耐药与肿瘤微环境相关性的研究进展,为该问题的解决提供可能的方向.
Research progress on the correlation between chemotherapy efficacy and tumor microenvironment in triple-negative breast cancer
Triple-negative breast cancer(TNBC)is characterized by tumor heterogeneity and diverse tumor microenvironment(TME),which make its research and treatment more difficult.Chemotherapy is an important TNBC treatment;however,predicting post-treatment effic-acy and chemoresistance remain urgent clinical challenges,with changes in the TME being a major cause.Understanding the facilitating role of the TME is crucial to resolve the challenges.In this study,we assessed the findings of multi-omics studies to explore the research progress on the correlation between the TME and clinical efficacy and chemotherapy resistance of TNBC.We hope to provide a possible direction to improve clinical efficacy and overcome chemotherapy resistance in TNBC.

triple-negative breast cancer(TNBC)tumor microenvironment(TME)chemotherapy resistancemulti-omics combination

黄愉棉、李红玉、孙刚

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新疆医科大学附属肿瘤医院乳腺甲状腺外科(乌鲁木齐市 830011)

新疆肿瘤学重点实验室

新疆医科大学附属肿瘤医院乳腺内科

新疆维吾尔自治区人民医院乳腺甲状腺外科

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三阴性乳腺癌 肿瘤微环境 化疗耐药 多组学联合

国家自然科学基金项目新疆维吾尔自治区天山英才-科技创新领军人才项目

820605202023TSLJ0038

2024

中国肿瘤临床
中国抗癌协会

中国肿瘤临床

CSTPCD北大核心
影响因子:1.32
ISSN:1000-8179
年,卷(期):2024.51(15)
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