Research progress on the correlation between chemotherapy efficacy and tumor microenvironment in triple-negative breast cancer
黄愉棉 1李红玉 2孙刚3
扫码查看
点击上方二维码区域，可以放大扫码查看
作者信息
1. 新疆医科大学附属肿瘤医院乳腺甲状腺外科(乌鲁木齐市 830011);新疆肿瘤学重点实验室
2. 新疆医科大学附属肿瘤医院乳腺内科
3. 新疆维吾尔自治区人民医院乳腺甲状腺外科
折叠
摘要
三阴性乳腺癌(triple-negative breast cancer,TNBC)明显的肿瘤异质性和多样的肿瘤微环境(tumor microenvironment,TME)特征加大了其研究和治疗的难度.化疗是TNBC治疗的重要手段之一,治疗后疗效预测及化疗耐药仍是临床亟待解决的难题,其中TME的变化是一个主要的原因.了解肿瘤微环境在其中起到的促进作用对这一困境的突破至关重要.本文综合多组学研究的结论,探讨了TNBC临床疗效及化疗耐药与肿瘤微环境相关性的研究进展,为该问题的解决提供可能的方向.
Abstract
Triple-negative breast cancer(TNBC)is characterized by tumor heterogeneity and diverse tumor microenvironment(TME),which make its research and treatment more difficult.Chemotherapy is an important TNBC treatment;however,predicting post-treatment effic-acy and chemoresistance remain urgent clinical challenges,with changes in the TME being a major cause.Understanding the facilitating role of the TME is crucial to resolve the challenges.In this study,we assessed the findings of multi-omics studies to explore the research progress on the correlation between the TME and clinical efficacy and chemotherapy resistance of TNBC.We hope to provide a possible direction to improve clinical efficacy and overcome chemotherapy resistance in TNBC.
关键词
三阴性乳腺癌/肿瘤微环境/化疗耐药/多组学联合
Key words
triple-negative breast cancer(TNBC)/tumor microenvironment(TME)/chemotherapy resistance/multi-omics combination
维普
万方数据