中国肿瘤临床2024，Vol.51Issue(20) ：1034-1038.DOI:10.12354/j.issn.1000-8179.2024.20241057

早期肺癌肿瘤微环境宿主免疫功能研究及与疾病进展的关联性

Study of host immune function in the tumor microenvironment of early-stage lung cancer and its correlation with disease progression

崔娟娟 王东东 杨光华 赵中
中国肿瘤临床2024，Vol.51Issue(20) ：1034-1038.DOI:10.12354/j.issn.1000-8179.2024.20241057
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  • 维普
  • 万方数据

早期肺癌肿瘤微环境宿主免疫功能研究及与疾病进展的关联性

Study of host immune function in the tumor microenvironment of early-stage lung cancer and its correlation with disease progression

崔娟娟 1王东东 1杨光华 1赵中2
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作者信息

  • 1. 驻马店市中心医院肿瘤内一科,河南省驻马店市463000
  • 2. 黄淮学院数学与统计学院
  • 折叠

摘要

目的:研究早期肺癌肿瘤微环境(tumor microenvironment,TME)宿主免疫功能及与病情进展的关联性.方法:回顾性分析2020年2月至2023年4月驻马店市中心医院216例早期肺癌患者的癌组织和癌旁组织免疫细胞的表达.根据患者是否复发分为复发组(41例)、未复发组(175例),比较两组基线资料、免疫细胞表达,分析免疫细胞表达对肺癌复发的影响及预测价值.结果:癌组织CD56+自然杀伤(natural killer,NK)阳性率低于癌旁组织,CD68+肿瘤相关巨噬细胞(tumor-associated macrophages,TAM)和CD163+TAM高浸润率及CD4+T细胞、CD8+T细胞比例高于癌旁组织,差异具有统计学意义(P<0.05);复发组肿瘤最大直径、有微乳头结构患者占比、CD68+TAM和CD163+TAM高浸润率及CD8+T细胞比例高于未复发组,CD56+NK阳性率低于未复发组,差异具有统计学意义(P<0.05);校正后显示CD56+NK阳性、CD68+TAM高浸润、CD163+TAM高浸润、CD8+T细胞比例是早期肺癌复发的独立相关影响因素,差异具有统计学意义(P<0.05);CD56+NK阳性+CD68+TAM高浸润+CD163+TAM高浸润+CD8+T细胞比例预测早期肺癌复发的AUC为0.949,高于单独的免疫指标,差异具有统计学意义(P<0.05).结论:早期肺癌患者TME宿主免疫功能与病情进展有关,CD56+NK阳性、CD68+TAM高浸润、CD163+TAM高浸润、CD8+T细胞比例联合有助于提高早期肺癌复发预测效能.

Abstract

Objective:To study the relationships between host immune function in the tumor microenvironment (TME) and early-stage lung cancer progression. Methods:A total of 216 patients with early-stage lung cancer admitted to Zhumadian Central Hospital between Febru-ary 2020 and April 2023 were included to analyze immune cell presence in cancer and adjacent tissues. The patients were assigned into a re-lapse group (41 cases) and a non-recurrence group (175 cases) based on their relapse status. Baseline data and immune cell expression in the two groups were compared to analyze the influence and predictive value of immune cell prevalence on lung cancer recurrence. Results:The proportion of CD56+natural killer (NK) cells was lower in cancer tissues than that in adjacent tissues. The infiltration rates of CD68+tu-mor-associated macrophages (TAMs) and CD163+TAMs,as well as the proportions of CD4+and CD8+T cells,were higher in adjacent tissues than in cancerous tissues (P<0.05). In the recurrence group,the maximum tumor diameter,proportion of patients with micro-papillary struc-tures,CD68+TAM and CD163+TAM infiltration rates,and CD8+T cell proportion were higher than those in the non-recurrent group,while the CD56+NK cell positive rate was lower (P<0.05). After correction,CD56+NK positivity,elevated CD68+TAM and CD163+TAM infiltration,and CD8+T cell proportion were independent factors associated with early-stage lung cancer recurrence (P<0.05). The AUC for predicting early-stage lung cancer recurrence using CD56+NK positivity+high CD68+TAM and CD163+TAM infiltration+proportion of CD8+T cells was 0.949,which was higher than that of each individual immune marker (P<0.05). Conclusions:Host immune function in the TME in patients with early lung cancer correlates with disease progression. The combination of high CD56+NK+,CD68+TAM infiltration,high CD163+TAM infiltration,and CD8+T-cell ratio can improve prediction efficiency for early lung cancer recurrence.

关键词

早期/肺癌/肿瘤微环境/宿主免疫功能/病情进展/关联性

Key words

early stage/lung cancer/tumor microenvironment (TME)/host immune function/disease progression/relevance

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出版年

2024
中国肿瘤临床
中国抗癌协会

中国肿瘤临床

CSTPCDCSCD北大核心
影响因子：1.32
ISSN：1000-8179
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