Diagnostic and therapeutic value of nonsense-mediated mRNA decay in cancer
Nonsense-mediated mRNA decay (NMD) serves as a quality control mechanism,degrading aberrant mRNAs with premature termination codons (PTCs). It also plays a role in growth and development,immune regulation,and is closely associated with the tumor microenvironment. NMD has a dual role in cancer;on the one hand,it inhibits tumor progression through down-regulation of pro-oncogenic protein expression,inhibition of pro-oncogenic signaling pathways and stressful microenvironments,while one the other hand,it promotes tumor progression by inhibiting oncogene expression,cancer cell apoptosis and tumor neoantigen production. Notably,NMD does not degrade all PTC-containing mRNAs. The location of the PTC may determine whether NMD is triggered or evaded. Since different genes vary greatly in high-frequency mutation regions,the likelihood of triggering NMD after a PTC mutation differs across genes. With the maturation and widespread use of second-generation sequencing technology,gene mutation screening has become a routine clinical diagnostic tool,making it possible to explore the patterns and significance of NMD from a multi-gene perspective. By further understanding the functions and mechanisms of NMD and assessing the NMD levels through high-throughput sequencing and computational algorithms,its potential clinical value is expected to be revealed,contributing to the advancement of personalized treatment and precision medicine.
万方数据
维普
