Comparison of serum inflammation cell and serum total IgE between chronic rhinosinusitis and allergic rhinitis
Background Both chronic rhinosinusitis and allergic rhinitis are nasal chronic inflammation diseases.The inflammation process is involved in a series of activating and chemotaxis of immune cells.Many cells form network and play an important role.However,the difference of the inflammatory cells and the medium remains unclear.Objective To compare the serum inflammatory cell and serum total IgE(tIgE)among chronic rhinosinusitis with nasal polyps group(CRSwNP,ab.wNP),chronic rhinosinusitis without nasal polyps group(CRSsNP,ab.sNP)and allergic rhinitis group.Methods A totle 61 chronic rhinosinusitis without nasal polyps patients(sNP),63 chronic rhinosinusitis with nasal polyps patients(wNP),60 allergic rhinitis patients(AR),and 50 normal controls were invovlved.Blood routine examination was detected by automatic blood cell counter.Serum inhalation allergen specific IgE and tIgE were detected by ImmunoCAP system.According to whether or not it is positive for the inhalation allergen,the sNP or wNP was divided into positive group or negative group,respectively.Such as sNP+、wNP+,and sNP-、wNP-.Then the serum total IgE and peripheral blood cells count and percentage were compared among groups.Results ①9 allergen positive and 52 allergen negative in sNPgroup;16 allergen positive and 47 allergen negative in wNPgroup.②There were significant differences for the serum IgE level,blood eosinophil count and basophilic granulocyte count among the AR,sNP-、wNP-and control(all P<0.05).Basophilic granulocyte percentage was lowest in AR,and highest in wNP-.The eosinophil percentage increased significantly in AR and wNP+(both P<0.01),while no change in sNP+.The-tIgE was the hightest in AR,wNP-was lower than AR while higher than sNP-(P<0.01).③There was significant difference for the eosinophil percentage,the basophilic granulocyte percentage and tIgE when compared among groups(P<0.05).The basophilic granulocyte percentage is lowest in AR group,while it has no difference between sNP+ and control,same as wNP+.The eosinophil percentage increased significantly in AR and sNP+、wNP+(both P<0.05),it was highest in AR.The tIgE also increased significantly in AR,sNP+ and wNP+ group when compared to control(P<0.01),and it was highest in AR,then wNP+,sNP+ in turn.④Correlation analysis showed tIgE has no association with the eosinophil percentage and basophilic granulocyte percentage(P>0.05).Conclusion eosinophil,basophilic granulocyte and tIgE may play a potential role in the mechanism of AR and nasal polyps.The peripheral blood eosinophil,basophilic granulocyte and serum tIgE are all increased in patients with nasal polyps,and may be used as a predictive index for the occurrence of nasal polyps.
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