Clinical observation on the therapeutic effect of Huanghe Decoction on allergic rhinitis
Objective To evaluate the therapeutic efficacy of Huanghe Decoction(HHD)on patients with allergic rhinitis in the pattern of Lung-Spleen Qi Deficiency(LSQD)in a comparative way and to evaluate its pharmacodynamic effects on the serum levels of some cytokines and IgE.Method A total of 177 patients with allergic rhinitis in the pattern of LSQD were randomly divided into chemical drug treating group(CDTG),herbal medicine treating group(HMTG)and a group treated by a combined therapy with the chemical drug and herbal medicine simultaneously(CTG),with 59,60 and 58 cases in each respectively.Cases in CDTG were treated by loratadine orally taken,ones in HMTG received the treatment by orally taken HHD,and those in CTG received a combined therapy with HHD and loratadine at the same time,all being treated for 14 days as one therapeutic course and given three courses continuously in total.All these cases were followed up for one year after the therapeutic courses ended.At the same time,determined among all these cases were the serum levels of antibody IgE as well as cytokines IL-4 and IFN-γ at the time points before treatment,by the ends of therapeutic course and following up period respectively.Then,comparatively analyzed were the scores of clinical symptoms and the changed tendencies of IgE,IL-4 and IFN-γ at the time points before treatment,and by the ends of therapeutic course and following up period respectively,with the total effective rates analyzed at the latter two time points among these three groups of patients as well.Result By the end of therapeutic courses,the total effective rate of CDTG was 52.5%,the one of HMTG was 71.6%,and that of CTG was 93.1%respectively,with significantly statistical significance among them(P<0.05).By the end of following up period,the total effective rate of CDTG was 37.2%,the one of HMTG was 58.3%,and that of CTG was 82.7%respectively,with the rates of HMTG and CTG being much higher than that of CTG(P<0.05),especially with the highest rate in CTG.Concerning their effects on serum levels of IgE,IL-4 and IFN-γ,cases in HMTG and CTG showed a significantly lowering tendency in the levels of IgE and IL-4,and an elevating trend in level of IFN-γ(P<0.05).There were no significant differences in the side effects occurred among these 3 groups(P>0.05).Conclusion Huanghe Decoction can bring about a definite clinical efficacy in the treatment of cases with allergic rhinitis in the pattern of Lung-Spleen Qi Deficiency.The efficacy of herbal medicine can be elevated further when used with anti-histamine drugs together,with no obvious side effects observed among them
NETL
NSTL
万方数据
