A study of the causal relationship between BMI and obstructive sleep apnea syudrome based on two-sample Mendelian randomization
Objective Investigate the causal relationship between Body Mass Index(BMI)and Obstructive Sleep Apnea Syndrome(OSAS).Methods From the summary data of large-scale genome-wide association studies,this study selected single nucleotide polymorphisms(SNPs)of BMI and OSAS that have intersected with each other as instrumental variables.Five methods,including Inverse Vance Weighted(IVW),Weighted Median,MR-Egger regression,Simple mode,and Weighted model,were used to conduct a two-sample Mendelian randomization analysis of the causal relationship between BMI and OSAS.Sensitivity analysis was also performed to ensure the robustness of the results.Results A total of 73 SNPs were included as instrumental variables.Inverse Variance Weighted(IVW),Weighted Median,MR-Egger regression,simple and weighted model ratio(odds ratio,OR),and 95%confidence interval(95%CI)were calculated:1.003713(1.002236～1.005193)、1.003747(1.001475～1.006023)、1.05433(1.001800～1.009079)、1.001333(0.995750～1.006947)、1.006834(1.002746～1.010939);all p-values were less than 0.001;sensitivity analysis showed robust results.Conclusion Elevated BMI may be a risk factor for OSAS.
mendelian randomizationbody mass Indexobstructive sleep apnea syndromegenome wide association study
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