Observation on the therapeutic effect of the combined therapy with olfactory training and nerve growth factor on patients with sensorineural olfactory dysfunction
Objective To observe the therapeutic effect of the combined therapy with olfactory training and nerve growth factor on patients with sensorineural olfactory dysfunction.Methods Thirty patients with olfactory dysfunction,caused by head trauma or upper respiratory tract infection recently treated in our hospital,were recruited as observation group(OG),while another group of 30 cases with olfactory dysfunction,caused by head trauma or upper respiratory tract infection as well treated in our hospital before,were collected as control group(CG).Cases in CG were instructed to use olfactory training and those in OG received a combined therapy with olfactory training and nerve growth factor therapy given via nasal approach.Scores of Sniffin Sticks were determined among the cases in both groups,carried out before treatment and 1 month as well as 3 months following treatment respectively.Then,compared were the effective rates of these two groups to evaluate the therapeutic effects of such therapies on the lesion.Results The total effective rate of OG was 66.67%,the one of CG was 33.33%,with statistical significance in the difference between the two groups(P<0.05).Moreover,the effective rates of the therapies among cases with the lesion induced by upper respiratory tract infection were 41.18%and 82.35%in CG and OG respectively,with markedly statistical significance in the difference between them(P<0.05).Furthermore,the scores of Sniffin Sticks detected at one month and three months following the treatment were all significantly improved in both groups(P<0.05),when compared with that determined before treatment,but the effective rates of CG and OG were 23.08%and 46.15%respectively for cases with olfactory dysfunction induced by trauma,with no significantly statistical significance(P>0.05).The scores determined at 3 months following treatment in the cases of OG with olfactory dysfunction induced by trauma was obviously superior to that before treatment(P<0.05),while the scores tested at 1 month following treatment in them was not significantly improved as compared with that tested before treatment(P>0.05).Conclusion The efficacy of the combined therapy with olfactory training and nerve growth factor should be superior to that of the simple therapy only with olfactory training in the treatment of olfactory dysfunction induced either by upper respiratory tract infection or by trauma.Therefore,this kind of combined therapy can be used as an effective treating strategy for sensorineural olfactory dysfunction in clinical practice.
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