Development and clinical validation of a taste stimulator and the verification of gustatory evoked potentials
Objective To develop a taste stimulator,build a gustatory evoked potential instrument based on it,and use the device to conduct clinical gustatory evoked potential tests to verify the feasibility,specificity and reliability of the system.Method An electric taste stimulator was developed,which included a taste agent delivery system,a programmable controller,a man-machine interface and a mouthpart for taste agent delivery.This stimulator can accurately release taste stimuli.Neuro-Audio EEG platform was used as EEG recording and analysis system.20 healthy subjects were recruited for the taste evoked potential test.Testing consisted of the use of odorless distilled water and different concentrations of brine(0.3%and 0.6%)as odorant testing.Stimulus 17 Superposition was performed,and the electrodes Cz and Fz were recorded.Results No EEG waveforms were recorded when distilled water was used as the stimulator,while the corresponding EEG waveforms were recorded when saline(0.3%and 0.6%)was used as the salty stimulator.Typical waveforms include P1,N1,P2 andN2,waves.These waveforms disappeared after topical anesthesia with tetracaine.In addition,with the increase of salty stimulus concentration,the latency of P1 and P2 recorded in Cz and Fz was significantly shortened,the difference was statistically significant.Conclusion The self-developed taste stimulator combined with EEG recording system can successfully record specific taste evoked potentials.
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