Serum sex hormone levels among male patients with obstructive sleep apnea hypopnea syndrome
Objective To investigate the clinicopathological implications of serum sex hormone levels among male patients with obstructive sleep apnea hypopnea syndrome(OSAHS).Methods Included in this trial were 102 male patients with OSAHS taken as the experimental group(EG),with another 80 patients with chronic tonsillitis as control(CG).Determined among these cases were their such serum levels of sex hormones as estradiol,testosterone and progestin by chemiluminescence immunoassay to evaluate their possible associations with such parameters of these patients as age,history of snoring and apnea,apnea hypopnea index(AHI),body mass index(BMI),neck circumference,abdominal circumference,blood pressure,smoking,drinking,severity of illness and palatopharyngeal stenosis,Epworth Sleeping Scale(ESS),and systemic comorbidities in a comparative way between the two groups.Results The serum testosterone level of EG were obviously lower than that of CG,while that of estrogen and progestin were determined with no significantly statistical differences between the two groups.Among the cases with OSAHS,the levels of testosterone and progestin were negatively correlated with such indicators as AHI,BMI,Epworth sleeping scale,neck circumference and abdominal circumference,while the levels of estrogen and the ratio of estrogen/testosterone(e/t)were positively correlated with AHI,BMI,Epworth sleeping scale,neck circumference and abdominal circumference(P<0.05).Furthermore,e/t ratio was gradually increased with age among them.Conclusion Estrogen level among male cases usually increase with the exacerbation of OSAHS,with its pathogenesis possibly associated with reduction of testosterone level or imbalance between testosterone and estrogen.Such an imbalance in the ratio of testosterone to estrogen may be the possible reason for the increased prevalence of OSA in the elder men.
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